Department of Biotechnology, University of Science and Technology, Bannu, KPK, Pakistan.
Bull Environ Contam Toxicol. 2012 Aug;89(2):229-33. doi: 10.1007/s00128-012-0684-x. Epub 2012 Jun 1.
The toxicological effects of the active ingredients of the herbicides diuron and bentazon on the activity of acetylcholinesterase (AChE) of krait (Bungarus sindanus) venom and electric eel (Electrophorus electricus) were studied. The diuron and entazon caused non-competitive inhibition of AChE from both species. For the venom AChE, the calculated IC50 for diuron and bentazon were found to be 3.25 and 0.14 μM, while for eel AChE, the respective IC50 values were 3.6 and 0.135 μM. In comparison, bentazon was a more potent inhibitor than diuron of AChE from both species. The insecticide lindane did not have any inhibitory effect on AChE activity in either species, even when tested at high concentrations (200-800 μM).
本研究旨在探讨除草剂敌草隆和苯达松的活性成分对眼镜蛇（Bungarus sindanus）毒液和电鳗（Electrophorus electricus）乙酰胆碱酯酶（AChE）活性的毒理学影响。敌草隆和苯达松对这两种 AChE 均表现为非竞争性抑制。对于毒液 AChE，敌草隆和苯达松的计算 IC50 值分别为 3.25 和 0.14 μM，而对于电鳗 AChE，相应的 IC50 值分别为 3.6 和 0.135 μM。相比之下，苯达松对两种 AChE 的抑制作用均强于敌草隆。即使在高浓度（200-800 μM）下测试，杀虫剂林丹对这两种 AChE 均无抑制作用。
