言语发育迟缓个体的亲属和自闭症谱系障碍个体的亲属存在沟通和社交缺陷。
Communication and social deficits in relatives of individuals with SLI and relatives of individuals with ASD.
机构信息
Biostatistics, Institute of Psychiatry, King's College London, London, UK.
出版信息
J Autism Dev Disord. 2013 Jan;43(1):156-67. doi: 10.1007/s10803-012-1556-2.
Abstract
We investigate two aspects of the autism triad, communication and social difficulties, in relatives of specific language impairment (SLI) probands (with and without additional autistic symptomatology) as compared to relatives of autism spectrum disorder (ASD) and Down's syndrome (DS) probands. Findings involving 726 first degree relatives of 85 SLI, 99 ASD and 36 DS probands revealed a higher rate of communication difficulties in relatives of both subgroups of SLI probands compared to ASD and DS relatives. Similar levels of social deficits were found in relatives of SLI + ASD and ASD probands. There was a higher than would be expected rate (4.3 %) of ASD, particularly in siblings of SLI + ASD probands. Communication and social deficits appear to breed true in SLI and ASD.
摘要
我们研究了自闭症三联征的两个方面，即交流和社交困难，在特定语言障碍 (SLI) 先证者的亲属（有和没有额外的自闭症症状）与自闭症谱系障碍 (ASD) 和唐氏综合征 (DS) 先证者的亲属进行了比较。涉及 85 名 SLI、99 名 ASD 和 36 名 DS 先证者的 726 名一级亲属的研究结果表明，与 ASD 和 DS 亲属相比，SLI 先证者的两个亚组的亲属中，交流困难的比率更高。在 SLI + ASD 和 ASD 先证者的亲属中，也发现了类似水平的社交缺陷。ASD 的发生率高于预期（4.3%），特别是在 SLI + ASD 先证者的兄弟姐妹中。交流和社交缺陷在 SLI 和 ASD 中似乎是真实存在的。
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