Lu C, Shen Y-J, Deng Y-F, Wang C-Y, Fan G, Liu Y-Q, Zhao S-M, Zhang B-C, Zhao Y-R, Wang Z-E, Zhang C-Z, Lu Z-M
Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, China.
Genet Mol Res. 2012 May 15;11(2):1370-8. doi: 10.4238/2012.May.15.7.
Killer cell immunoglobulin-like receptors (KIRs) are involved in the pathogenesis of a variety of diseases. However, whether KIR polymorphism is associated with susceptibility to pulmonary tuberculosis was unknown. We examined a possible association of KIR polymorphism with susceptibility to pulmonary tuberculosis in Chinese Han. We analyzed 15 KIR genes in 109 pulmonary tuberculosis patients and 110 healthy controls using sequence-specific primer PCR analysis of genomic DNA. We found that the frequencies of KIR2DS1, 2DS3 and 3DS1 were significantly higher in patients than in the control group. In addition, the number of subjects carrying more than two activating KIR genes in the patient group was significantly higher than in the control group. The gene cluster containing KIR3DS1-2DL5-2DS1-2DS5 was also significantly more frequent in the patient group. In conclusion, KIR genes 2DS1, 2DS3 and 3DS1 appear to be associated with resistance to pulmonary tuberculosis in the Chinese Han population. KIR genes apparently have a role in resistance to pulmonary tuberculosis.
杀伤细胞免疫球蛋白样受体（KIRs）参与多种疾病的发病机制。然而，KIR基因多态性是否与肺结核易感性相关尚不清楚。我们研究了中国汉族人群中KIR基因多态性与肺结核易感性之间的可能关联。我们采用基因组DNA序列特异性引物PCR分析法，对109例肺结核患者和110名健康对照者的15个KIR基因进行了分析。我们发现，患者组中KIR2DS1、2DS3和3DS1的频率显著高于对照组。此外，患者组中携带两个以上激活型KIR基因的受试者数量显著高于对照组。患者组中包含KIR3DS1-2DL5-2DS1-2DS5的基因簇也明显更为常见。总之，KIR基因2DS1、2DS3和3DS1似乎与中国汉族人群对肺结核的抵抗力相关。KIR基因显然在抵抗肺结核中发挥作用。
