University of California Los Angeles Biomedical Engineering Interdepartmental Program, Los Angeles, CA 90095, USA.
Science. 2012 Jun 1;336(6085):1129. doi: 10.1126/science.1219351.
Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials.
设计能够组装成各种有序材料的蛋白质分子是纳米技术中的一个重要挑战。我们报告了一种 12 个亚基蛋白质笼的晶体结构，它通过设计自组装形成一个大致 16 纳米直径的四面体结构。融合寡聚蛋白结构域的策略可以推广到产生其他类型的笼状或扩展材料。
