Cavaliere A, Pietropaoli N, Alberti P F, Vitali R
Institute of Pathological Anatomy and Histology, Perugia University, Italy.
Cancer Lett. 1990 Dec 3;55(2):115-20. doi: 10.1016/0304-3835(90)90020-x.
Chlorambucil, a drug used in the treatment of neoplastic and non-neoplastic disease, was administered by gavage to BALB/c mice at a dose of 1.0 mg/kg body wt. 5 times per week for 12 weeks to test its carcinogenicity. The survival was statistically reduced in treated animals of both sexes (P less than 0.001). The treatment induced a significant increase in lung tumours (males, P less than 0.001; females, P less than 0.001) and lymphoreticular system tumours (males P less than 0.01; females, P less than 0.001) in both sexes and mammary carcinomas in female mice (P less than 0.05). These results with other investigations reported in literature, suggest that chlorambucil is carcinogenic in laboratory animals, mutagenic and that it could be a potential carcinogenic hazard to man.
苯丁酸氮芥是一种用于治疗肿瘤性和非肿瘤性疾病的药物，以1.0毫克/千克体重的剂量通过灌胃法给予BALB/c小鼠，每周5次，持续12周，以测试其致癌性。经治疗的两性动物存活率在统计学上降低（P<0.001）。该治疗使两性的肺肿瘤（雄性，P<0.001；雌性，P<0.001）、淋巴网状系统肿瘤（雄性，P<0.01；雌性，P<0.001）以及雌性小鼠的乳腺癌（P<0.05）显著增加。这些结果以及文献中报道的其他研究表明，苯丁酸氮芥在实验动物中具有致癌性、致突变性，并且可能对人类构成潜在的致癌风险。
