Cavaliere A, Bufalari A, Vitali R
Institute of Pathological Anatomy and Histology, Division of Cancer Research, Perugia, Italy.
Cancer Lett. 1987 Oct;37(1):51-8. doi: 10.1016/0304-3835(87)90145-5.
5-Azacytidine, a drug used in the treatment of acute leukaemias and beta-thalassemia, was administered i.p. to BALB/c mice at a dose of 2.0 mg/kg body wt. once a week for 50 weeks to test its carcinogenicity. The treatment induced a significant increase in lung tumours (males P less than 0.001, females P less than 0.05), lymphomas (males P less than 0.01, females P less than 0.01), skin tumours (males P less than 0.05, females P less than 0.01) in both sexes and mammary carcinomas (P less than 0.01) and a variety of other tumours in female mice. These results, with other investigations reported in literature, suggest that 5-azacytidine is carcinogenic in mice.
5-氮杂胞苷是一种用于治疗急性白血病和β地中海贫血的药物，以2.0毫克/千克体重的剂量腹腔注射给BALB/c小鼠，每周一次，共50周，以测试其致癌性。该治疗导致雄性小鼠的肺肿瘤（P<0.001）、淋巴瘤（P<0.01）、皮肤肿瘤（P<0.05）以及雌性小鼠的肺肿瘤（P<0.05）、淋巴瘤（P<0.01）、皮肤肿瘤（P<0.01）、乳腺癌（P<0.01）和多种其他肿瘤显著增加。这些结果与文献中报道的其他研究表明，5-氮杂胞苷在小鼠中具有致癌性。
