Cavaliere A, Alberti P F, Vitali R
Institute of Pathological Anatomy and Histology, 1st Chair, Perugia University, Italy.
Tumori. 1990 Apr 30;76(2):179-81. doi: 10.1177/030089169007600205.
5-Fluorouracil, a drug mainly used in the treatment of gastrointestinal tract neoplasms, was administered i.p. to BALB/c mice at the dose of 30 mg/kg body weight once a week for 50 weeks to test its carcinogenicity. The treatment induced a significant increase in lung tumor in both sexes (males, p less than 0.05; females, p less than 0.01) and tumors of the lymphoreticular system in female mice (p less than 0.001). These results suggest that 5-fluorouracil is carcinogenic in mice.
5-氟尿嘧啶是一种主要用于治疗胃肠道肿瘤的药物，以30毫克/千克体重的剂量每周一次腹腔注射给BALB/c小鼠，持续50周，以测试其致癌性。该治疗导致两性的肺肿瘤显著增加（雄性，p<0.05；雌性，p<0.01），以及雌性小鼠淋巴网状系统肿瘤增加（p<0.001）。这些结果表明5-氟尿嘧啶在小鼠中具有致癌性。
