Popdc3 表达降低与胃癌患者的高风险和不良预后相关。
Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer.
机构信息
Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
出版信息
World J Gastroenterol. 2012 May 21;18(19):2423-9. doi: 10.3748/wjg.v18.i19.2423.
AIM
To investigate the expression of Popeye domain containing 3 (Popdc3) and its correlation with clinicopathological features and prognosis of gastric cancer.
METHODS
The method of immunohistochemistry was used to investigate the expression of Popdc3 in 306 cases of human gastric cancer and 84 noncancerous gastric tissues. Simultaneously, the relationship between Popdc3 expression and the survival of the patients was retrospectively analyzed.
RESULTS
Popdc3 was detected in 72 (85.71%) of 84 human nontumor mucosa. High expression of Popdc3 protein was detected in 78 (25.49%) of 306 human gastric cancer cases, and low expression was detected in 228 (74.51%). Low expression of Popdc3 correlated with depth of invasion (P < 0.0001), regional lymph nodes (P < 0.0001) and distant metastasis (P = 0.02), and tumor, nodes, metastasis (TNM) stages (P < 0.0001). On multivariate analysis, only the patient's gender, regional lymph node metastasis, distant metastasis, TNM stages, and the expression of Popdc3 were independent prognostic factors in patients with gastric cancer. The Kaplan-Meier plot showed that low Popdc3 expression had a much more significant effect on the survival of those patients with early-stage tumors (χ² = 104.741, P < 0.0001), with a > 51.9% reduction in the three-year survival compared with high Popdc3 expression. In late stages, the difference was also significant (χ² = 5.930, P = 0.015), with a 32.6% reduction in the three-year survival.
CONCLUSION
Reduced expression of Popdc3 may play a significant role in the carcinogenesis and progression of gastric cancer. Popdc3 may be an independent prognostic factor.
目的
研究 Popeye 结构域包含蛋白 3（Popdc3）的表达及其与胃癌临床病理特征和预后的关系。
方法
采用免疫组织化学方法检测 306 例胃癌组织和 84 例非癌性胃组织中 Popdc3 的表达情况，并对患者的生存情况进行回顾性分析。
结果
在 84 例非肿瘤胃黏膜组织中，72 例（85.71%）检测到 Popdc3。在 306 例胃癌组织中，78 例（25.49%）高表达 Popdc3 蛋白，228 例（74.51%）低表达。Popdc3 低表达与浸润深度（P < 0.0001）、区域淋巴结（P < 0.0001）和远处转移（P = 0.02）以及肿瘤、淋巴结、转移（TNM）分期（P < 0.0001）有关。多因素分析显示，仅患者的性别、区域淋巴结转移、远处转移、TNM 分期和 Popdc3 的表达是胃癌患者的独立预后因素。Kaplan-Meier 图显示，Popdc3 低表达对早期肿瘤患者的生存影响更为显著（χ² = 104.741，P < 0.0001），与高 Popdc3 表达相比，三年生存率降低超过 51.9%。在晚期，差异也很显著（χ² = 5.930，P = 0.015），三年生存率降低 32.6%。
结论
Popdc3 表达降低可能在胃癌的发生和发展中起重要作用，Popdc3 可能是一个独立的预后因素。
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