MnTE-2-PyP对哮喘小鼠模型肺部的抗氧化作用。
Antioxidant effect of MnTE-2-PyP on lung in asthma mice model.
作者信息
Terziev Lyudmil, Dancheva Violeta, Shopova Veneta, Stavreva Galya
机构信息
Sector of Clinical Immunology and Allergology, Pelven Medical University, 5800 Pleven, Bulgaria.
出版信息
ScientificWorldJournal. 2012;2012:379360. doi: 10.1100/2012/379360. Epub 2012 Apr 30.
AIM
To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model.
MATERIAL AND METHODS
The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate.
RESULTS
The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2.
CONCLUSIONS
The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.
目的
研究 MnTE-2-PyP 对哮喘小鼠模型抗氧化防御系统某些标志物的影响。
材料与方法
将动物分为四组：第 1 组为对照组；第 2 组注射卵清蛋白；第 3 组用 MnTE-2-PyP 治疗；第 4 组用卵清蛋白和 MnTE-2-PyP 治疗。测定肺匀浆中超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶的活性以及非蛋白巯基含量（NPSH）。
结果
与对照组相比，第 2 组中超氧化物歧化酶和过氧化氢酶的活性显著降低。与第 2 组相比，第 4 组中相同酶的降低幅度较小且具有显著性。谷胱甘肽过氧化物酶活性的变化呈现相似的动态。第 2 组中 NPSH 含量降低。与第 2 组相比，第 4 组中这种降低相对较小。
结论
MnTE-2-PyP 的应用减轻了哮喘小鼠模型中氧化应激的影响。
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