Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain.
Front Endocrinol (Lausanne). 2011 Aug 11;2:21. doi: 10.3389/fendo.2011.00021. eCollection 2011.
The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis, and neurite development in the nervous system. Estradiol, acting as a hormonal signal or as a neurosteroid, also regulates these developmental processes. Here we review recent evidence indicating that estradiol and Notch signaling interact in developing hippocampal neurons by a mechanism involving the putative membrane receptor G protein-coupled receptor 30. This interaction is relevant for the control of neuronal differentiation, since the downregulation of Notch signaling by estradiol results in the upregulation of neurogenin 3, which in turn promotes dendritogenesis.
跨膜受体 Notch 是一种主要的发育调节剂，它控制着神经系统中的神经发生、神经发生和神经突发育。雌激素作为一种激素信号或神经甾体，也调节这些发育过程。在这里，我们回顾了最近的证据，表明雌激素和 Notch 信号通过涉及假定的膜受体 G 蛋白偶联受体 30 的机制相互作用于发育中的海马神经元。这种相互作用与神经元分化的控制有关，因为雌激素对 Notch 信号的下调导致神经生成素 3 的上调，进而促进树突发生。
