阴茎癌的化疗。
Chemotherapy in penile cancer.
机构信息
Urologische Universitätsklinik Ernst-Heydemann-Strasse 6 D-18059 Rostock Germany.
出版信息
Ther Adv Urol. 2012 Jun;4(3):133-8. doi: 10.1177/1756287212441235.
Abstract
Penile cancer is an aggressive disease and after systemic progression it is virtually incurable. While this squamous cell cancer responds to chemotherapy, successful treatment of lymphatic metastases can only be achieved with aggressive surgical treatment in combination with chemotherapy. However, because penile carcinoma is relatively rare there is a paucity of clinical data on the chemotherapy for this aggressive disease. Recent advances have included the establishment of less toxic regimens incorporating taxanes, while cisplatinum remains central to all regimens. Multi-institutional studies are urgently needed to advance the multimodal care for patients with penile cancer.
摘要
阴茎癌是一种侵袭性疾病，全身性进展后几乎无法治愈。虽然这种鳞状细胞癌对化疗有反应，但只有通过积极的手术治疗联合化疗才能成功治疗淋巴转移。然而，由于阴茎癌相对罕见，因此针对这种侵袭性疾病的化疗临床数据较少。最近的进展包括建立包含紫杉烷类药物的毒性较小的方案，而顺铂仍然是所有方案的核心。迫切需要多机构研究来推进阴茎癌患者的多模式治疗。
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