Department of Neurology, 2nd Hospital of Shandong University, Jinan City, Shandong Province, People's Republic of China.
PLoS One. 2012;7(5):e37937. doi: 10.1371/journal.pone.0037937. Epub 2012 May 24.
Fragile X syndrome is caused by the loss of the FMR1 gene product, fragile X mental retardation protein (FMRP). The loss of FMRP leads to altered circadian rhythm behaviors in both mouse and Drosophila; however, the molecular mechanism behind this phenomenon remains elusive. Here we performed a series of gene expression analyses, including of both mRNAs and microRNAs (miRNAs), and identified a number of mRNAs and miRNAs (miRNA-1 and miRNA-281) with circadian rhythm-dependent altered expression in dfmr1 mutant flies. Identification of these RNAs lays the foundation for future investigations of the molecular pathway(s) underlying the altered circadian rhythms associated with loss of dFmr1.
脆性 X 综合征是由 FMR1 基因产物脆性 X 智力低下蛋白（FMRP）的缺失引起的。FMRP 的缺失导致了小鼠和果蝇昼夜节律行为的改变；然而，这一现象背后的分子机制仍难以捉摸。在这里，我们进行了一系列的基因表达分析，包括 mRNA 和 microRNAs（miRNAs），并在 dfmr1 突变果蝇中鉴定出了一些具有昼夜节律依赖性表达改变的 mRNA 和 miRNAs（miRNA-1 和 miRNA-281）。这些 RNA 的鉴定为进一步研究与 dFmr1 缺失相关的昼夜节律改变的分子途径奠定了基础。
