Department of Plant Pathology, University of Wisconsin, Madison, Wisconsin 53706, USA.
Annu Rev Phytopathol. 2012;50:241-66. doi: 10.1146/annurev-phyto-081211-172936. Epub 2012 May 29.
Bacterial food-borne pathogens use plants as vectors between animal hosts, all the while following the life cycle script of plant-associated bacteria. Similar to phytobacteria, Salmonella, pathogenic Escherichia coli, and cross-domain pathogens have a foothold in agricultural production areas. The commonality of environmental contamination translates to contact with plants. Because of the chronic absence of kill steps against human pathogens for fresh produce, arrival on plants leads to persistence and the risk of human illness. Significant research progress is revealing mechanisms used by human pathogens to colonize plants and important biological interactions between and among bacteria in planta. These findings articulate the difficulty of eliminating or reducing the pathogen from plants. The plant itself may be an untapped key to clean produce. This review highlights the life of human pathogens outside an animal host, focusing on the role of plants, and illustrates areas that are ripe for future investigation.
细菌食源性病原体利用植物作为动物宿主之间的载体，同时遵循与植物相关细菌的生命周期脚本。类似于植物细菌，沙门氏菌、致病性大肠杆菌和跨域病原体在农业生产区都有立足之地。环境污染的共性是与植物接触。由于对新鲜农产品缺乏针对人类病原体的杀灭步骤，病原体到达植物上会导致持续存在并增加人类患病的风险。大量的研究进展揭示了人类病原体在植物上定植的机制以及植物体内细菌之间的重要生物学相互作用。这些发现说明了从植物中消除或减少病原体的难度。植物本身可能是生产清洁农产品的未开发关键。本综述强调了人类病原体在动物宿主之外的生活，重点介绍了植物的作用，并说明了未来有潜力进行研究的领域。
