免疫印迹分析辅助诊断感染利什曼原虫引起的皮肤利什曼病。
Western blot analysis as an aid for the diagnosis of cutaneous leishmaniasis due to Leishmania major.
机构信息
Faculté de Médecine, Université de Nice-Sophia Antipolis, Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Nice, Nice, France.
出版信息
Trans R Soc Trop Med Hyg. 2012 Jul;106(7):452-4. doi: 10.1016/j.trstmh.2012.03.001. Epub 2012 May 30.
Cutaneous leishmaniasis (CL) due to Leishmania major is endemic in the Old World. To evaluate the diagnostic value of Western blot (WB) compared with IFAT, we tested serum samples from 45 patients with proven CL. Twenty-one (47%) patients were positive by IFAT and all patients were positive by WB with specific bands against 14kDa and/or 18kDa Leishmania antigens. Our results suggest that WB could be a useful non-invasive tool for the diagnosis of CL caused by L. major.
皮肤利什曼病（CL）由利什曼原虫引起，在旧世界流行。为了评估 Western blot（WB）与 IFAT 的诊断价值，我们检测了 45 例确诊 CL 患者的血清样本。21 例（47%）患者 IFAT 阳性，所有患者 WB 均针对 14kDa 和/或 18kDa 利什曼原虫抗原呈特异性带阳性。我们的结果表明，WB 可能是诊断由 L. major 引起的 CL 的一种有用的非侵入性工具。
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