Liu Shengxiu, Yang Chunjun, Yang Sen, Wang Zhongying, Luo Difeng, Zhang Xuejun
Institute of Dermatology and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, People's Republic of China.
J Cosmet Laser Ther. 2012 Aug;14(4):189-92. doi: 10.3109/14764172.2012.699677.
To evaluate the effectiveness and safety of topical application of 5-aminolevulinic acid (ALA) followed by pulsed dye laser (PDL) irradiation for the treatment of recalcitrant port-wine stain (PWS).
Thirty-five patients (19 females and 16 males) with recalcitrant PWS were treated with topical application of 20% ALA and then irradiated with a 595-nm PDL (energy density of 6.5-9.0 J/cm(2) and pulse duration of 6 or 10 ms) at 6-8 weeks intervals. Clinical improvement of lesions was evaluated by comparing photographs of lesions at baseline and 2 months after the last treatment.
Topical ALA spreading followed by irradiation with a 595-nm PDL improved PWS in 21 out of 35 patients who were previously recalcitrant to PDL treatment alone. Side effects were limited to transient erythema, vesicle formation, edema and mild purpura with no obvious subsequent scarring or undesirable pigment changes.
The topical application of ALA followed by irradiation with a 595-nm PDL is an effective and safe treatment for PWS recalcitrant to PDL therapy alone.
评估外用5-氨基酮戊酸（ALA）后联合脉冲染料激光（PDL）照射治疗难治性葡萄酒色斑（PWS）的有效性和安全性。
35例难治性PWS患者（19例女性，16例男性）外用20% ALA，然后每隔6-8周用595nm的PDL照射（能量密度为6.5-9.0 J/cm²，脉冲持续时间为6或10毫秒）。通过比较基线时和最后一次治疗后2个月的皮损照片来评估皮损的临床改善情况。
在35例先前单独使用PDL治疗无效的患者中，外用ALA后再用595nm的PDL照射使21例患者的PWS得到改善。副作用仅限于短暂的红斑、水疱形成、水肿和轻度紫癜，无明显的后续瘢痕形成或不良色素改变。
外用ALA后联合595nm的PDL照射是一种治疗单独使用PDL治疗无效的PWS的有效且安全的方法。
