Alster Tina S, Tanzi Elizabeth L
Washington Institute of Dermatologic Laser Surgery, 2311 M Street, NW Suite 200, Washington, DC 20037, USA.
J Drugs Dermatol. 2003 Oct;2(5):501-4.
Successful and long-standing eradication of sebaceous hyperplasia has remained difficult due to the propensity of these lesions to be extensive. Current treatments include excision, electrodesiccation, laser vaporization, and oral isotretinoin, each often associated with unacceptable side effects or lesional recurrence. The purpose of this study was to evaluate the safety and effectiveness of laser-assisted photodynamic therapy using topical 5-aminolevulinic acid (5-ALA) and 595 nm pulsed dye laser (PDL) irradiation for the treatment of sebaceous hyperplasia. Ten patients with sebaceous hyperplasia received 1 or 2 treatments at 6 week intervals with topical 20% 5-ALA followed 1 hour later by 595 nm PDL irradiation. Matched lesions served as controls and were either treated with PDL alone or were left untreated. Patients were evaluated at regular intervals for 3 months. Results demonstrated that combination topical 5-ALA and PDL treatment effected better clinical results than PDL treatment alone. No changes were observed in untreated control lesions. Side effects were mild and limited to transient erythema, edema, and focal crusting. It is the conclusion of the authors that laser-assisted photodynamic therapy with topical 5-ALA and PDL irradiation can achieve safe and effective improvement of sebaceous hyperplasia. Further study is warranted to determine the longevity of the clinical results observed.
由于这些皮脂腺增生性病变往往范围广泛，长期成功根除一直很困难。目前的治疗方法包括切除、电干燥、激光汽化和口服异维A酸，每种方法常常伴有难以接受的副作用或病变复发。本研究的目的是评估使用外用5-氨基酮戊酸（5-ALA）和595nm脉冲染料激光（PDL）照射进行激光辅助光动力疗法治疗皮脂腺增生的安全性和有效性。10例皮脂腺增生患者每隔6周接受1或2次治疗，外用20% 5-ALA，1小时后进行595nm PDL照射。配对的病变作为对照，单独接受PDL治疗或不治疗。对患者进行为期3个月的定期评估。结果表明，外用5-ALA与PDL联合治疗比单独使用PDL治疗具有更好的临床效果。未治疗的对照病变未观察到变化。副作用轻微，仅限于短暂的红斑、水肿和局部结痂。作者得出结论，外用5-ALA和PDL照射的激光辅助光动力疗法可安全有效地改善皮脂腺增生。有必要进行进一步研究以确定所观察到的临床效果的持久性。
