Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 640, Taiwan.
Biotechnol Adv. 2013 May-Jun;31(3):362-8. doi: 10.1016/j.biotechadv.2012.05.005. Epub 2012 May 30.
An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells.
一种基于 X 射线辐射的原始合成方法产生了具有两种用于生物医学研究的重要性质的金纳米粒子（AuNPs）：强烈的可见光致发光和在癌细胞中的非常高的积累。涂有 MUA（11-巯基十一酸）的纳米粒子非常小（直径 1.4nm）；即使尺寸稍大，也不会出现上述两种性质。小的 MUA-AuNPs 是非细胞毒性的（除非浓度非常高），并且不会干扰癌细胞的增殖。通过追踪载有纳米粒子的肿瘤细胞，证明了使用可见光荧光和 X 射线显微镜的多模态成像。
