Soares Juliana K B, Rocha-de-Melo Ana P, Medeiros Maria C, Queiroga Rita C R E, Bomfim Marco A D, de Souza Amanda F O, Nascimento Ana L V, Guedes Rubem C A
Laboratório de Fisiologia da Nutrição Naíde Teodósio, Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Biochim Biophys Acta. 2012 Oct;1820(10):1490-5. doi: 10.1016/j.bbagen.2012.05.010. Epub 2012 Jun 1.
Conjugated linoleic acids (CLA) are fatty acids that are found in the lipids from goat milk, and appear to protect neurons from excitotoxicity.
We investigated in developing rats the effects of a maternal CLA-rich diet (containing 7% lipids from goat milk) on body development and cerebral electrical activity of the progeny from dams receiving the CLA diet during gestation (G), lactation (L) or both periods (G+L).
Compared to a control group (C) receiving a diet with 7% soybean oil, body weight increased at 14, 21 and 28 days, but not at 35-45 days, in L and G+L groups (P<0.05). No intergroup difference was found on body and brain weights, body length, abdominal and thoracic circumferences, body mass index and abdominal to thoracic circumference ratio at 35-45 days. In contrast, at this later age the CSD velocities of propagation were significantly higher (P<0.05) in L as compared with the C and G group, and in the L+G, as compared with the C, G and L groups, suggesting a long-lasting brain effect.
These data indicate that a maternal CLA-rich diet can differentially influence body weight increment (short-term effect), and CSD propagation (long-term effect) in the progeny, and the lactation is the most critical period for such diet actions.
The facilitating effect of the lipids from goat milk on an excitability-related phenomenon in the brain (CSD) can be of clinical relevance, since CSD has been associated to neurological disturbances like migraine and epilepsy.
共轭亚油酸（CLA）是存在于山羊奶脂质中的脂肪酸，似乎能保护神经元免受兴奋毒性。
我们研究了在发育中的大鼠中，母体富含CLA的饮食（含有7%的山羊奶脂质）对在妊娠（G）、哺乳（L）或两个时期（G+L）接受CLA饮食的母鼠后代的身体发育和脑电活动的影响。
与接受含7%大豆油饮食的对照组（C）相比，L组和G+L组在14、21和28天时体重增加，但在35 - 45天时未增加（P<0.05）。在35 - 45天时，各组在体重、脑重、体长、腹围和胸围、体重指数以及腹围与胸围之比方面未发现组间差异。相比之下，在这个较晚的年龄，与C组和G组相比，L组的皮层扩散性抑制（CSD）传播速度显著更高（P<0.05），与C组、G组和L组相比，L+G组的CSD传播速度也显著更高，这表明存在长期的脑效应。
这些数据表明，母体富含CLA的饮食可对后代的体重增加（短期效应）和CSD传播（长期效应）产生不同影响，而哺乳期是这种饮食作用的最关键时期。
山羊奶脂质对大脑中与兴奋性相关现象（CSD）的促进作用可能具有临床相关性，因为CSD与偏头痛和癫痫等神经紊乱有关。
