2nd Clinic of Internal Medicine, Masaryk University of Brno, Czech Republic.
J Atheroscler Thromb. 2012;19(5):453-61. doi: 10.5551/jat.9639. Epub 2012 Jan 12.
The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls.
82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9±14.9 years, were examined. CAVI was measured using the system VaSera® 1500.
CAVI in FH patients was significantly higher (8.0±1.4) than in healthy subjects (7.5±1.3) p = 0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p = 0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7).
The study showed no significant difference in CAVI between heterozygous FH and healthy controls.
心血管踝臂指数（CAVI）是一种新的动脉僵硬度和动脉粥样硬化的非侵入性标志物。本研究旨在比较杂合子家族性高胆固醇血症（FH）患者和健康对照者的 CAVI。
共纳入 82 例 FH 患者（27 名男性，65 名女性），年龄 53.7±13.6 岁，无心血管疾病的临床症状，以及 359 名健康对照者（121 名男性，238 名女性），年龄 43.9±14.9 岁。使用 VaSera®1500 系统测量 CAVI。
FH 患者的 CAVI 显著高于健康受试者（8.0±1.4），p=0.002；然而，年龄、性别和 BMI 校正后的 CAVI 在 FH 组（7.5，CI：7.3；7.7）和对照组（7.7，CI：7.6；7.7）之间无显著差异（p=0.061）。
该研究表明，杂合子 FH 与健康对照者之间的 CAVI 无显著差异。
