地中海普通人群中经典心血管危险因素及生活方式与心-踝血管指数的关联

Association of Classic Cardiovascular Risk Factors and Lifestyles With the Cardio-ankle Vascular Index in a General Mediterranean Population.

作者信息

Elosua-Bayés Marc, Martí-Lluch Ruth, García-Gil María Del Mar, Camós Lourdes, Comas-Cufí Marc, Blanch Jordi, Ponjoan Anna, Alves-Cabratosa Lia, Elosua Roberto, Grau María, Marrugat Jaume, Ramos Rafel

机构信息

Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain.

Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Barcelona, Spain; Grup Investigació en Salut Cardiovascular de Girona (ISV-Girona), Unitat de Recerca en Atenció Primària, Serveis en Atenció Primària, Institut Català de Salut (ICS), Girona, Spain; Institut d'Investigació Biomèdica de Girona (IdIBGi), ICS, Girona, Spain.

出版信息

Rev Esp Cardiol (Engl Ed). 2018 Jun;71(6):458-465. doi: 10.1016/j.rec.2017.09.011. Epub 2017 Oct 25.

DOI:10.1016/j.rec.2017.09.011

PMID:29079281

Abstract

INTRODUCTION AND OBJECTIVES

The cardio-ankle vascular index (CAVI) assesses arterial stiffness. We aimed to describe the distribution of CAVI in a Mediterranean population, to determine the proportion of CAVI ≥ 9 by sex and coronary risk level, and to assess the association of CAVI with classic cardiovascular risk factors and lifestyle patterns.

METHODS

This cross-sectional study was based on the population of Girona province. The CAVI was measured using the VaSera VS-1500.

RESULTS

Of 2613 individuals included in this study, the prevalence of CAVI ≥ 9 was 46.8% in men and 36.0% in women and significantly increased with coronary risk: from 21.1% and 24.8%, respectively to 76.7%, in the low-risk group, and 61.9% in the high-risk group. The CAVI increased with age in both sexes, being higher in men across all age groups. In men, CAVI ≥ 9 was associated with hypertension (OR, 2.70; 95%CI, 1.90-3.87) and diabetes (OR, 2.38; 95%CI, 1.52-3.78), body mass index (BMI) ≤ 25 to < 30 (OR, 0.44; 95%CI, 0.27-0.72) and BMI ≥ 30 (OR, 0.28; 95%CI, 0.14-0.58), and physical activity (OR, 0.66; 95%CI, 0.47-0.92). In women, CAVI ≥ 9 was associated with hypertension (OR, 2.22; 95%CI, 1.59-3.09), hypercholesterolemia (OR, 1.40; 95%CI, 1.01-1.94), and BMI ≥ 30 (OR, 0.38; 95%CI, 0.20-0.71).

CONCLUSIONS

The CAVI increases with age and is higher in men than in women. This index is associated with classic risk factors and coronary risk. It could be a good predictive biomarker, but further follow-up studies are required to assess its added value to cardiovascular risk stratification.

摘要

引言与目的

心踝血管指数（CAVI）用于评估动脉僵硬度。我们旨在描述地中海人群中CAVI的分布情况，确定按性别和冠心病风险水平划分的CAVI≥9的比例，并评估CAVI与经典心血管危险因素及生活方式模式之间的关联。

方法

这项横断面研究以赫罗纳省的人群为基础。使用VaSera VS - 1500测量CAVI。

结果

在本研究纳入的2613名个体中，CAVI≥9的患病率在男性中为46.8%，在女性中为36.0%，且随冠心病风险显著增加：在低风险组中，分别从21.1%和24.8%增至76.7%，在高风险组中为61.9%。CAVI在两性中均随年龄增长而升高，在所有年龄组中男性的CAVI更高。在男性中，CAVI≥9与高血压（比值比[OR]，2.70；95%置信区间[CI]，1.90 - 3.87）、糖尿病（OR，2.38；95%CI，1.52 - 3.78）、体重指数（BMI）≤25至<30（OR，0.44；95%CI，0.27 - 0.72）以及BMI≥30（OR，0.28；95%CI，0.14 - 0.58）和身体活动（OR，0.66；95%CI，0.47 - 0.92）相关。在女性中，CAVI≥9与高血压（OR，2.22；95%CI，1.59 - 3.09）、高胆固醇血症（OR，1.40；95%CI，1.01 - 1.94）以及BMI≥30（OR，0.38；95%CI，0.20 - 0.71）相关。