Chen Wei, Shi Xiaofeng, Liu Yunsheng, Li Cui, Xiao Zhiqiang, Liu Zhixiong
Department of Neurosurgery, Longgang Central Hospital of Shenzhen, Shenzhen, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 May;37(5):481-4. doi: 10.3969/j.issn.1672-7347.2012.05.009.
To explore whether oncogenes DJ-1 and HSP27 are associated with invasiveness of human pituitary adenoma.
Total proteins were extracted from samples of 20 invasive and 20 non-invasive pituitary adenomas and the expression of DJ-1 and HSP27 was analyzed by Western blot. The correlation of DJ-1and HSP27 with the invasiveness of pituitary adenoma was analyzed.
The strong positive rates of DJ-1 and HSP27 in the 20 invasive pituitary adenoma were 70% (14/20) and 80% (16/20), respectively. The invasive group had significantly higher expression of DJ-1 and HSP27 proteins than the noninvasive group [10% (2/20), 10% (2/20), respectively]. There was a positive correlation between the expression of DJ-1, HSP27 proteins and the invasiveness of pituitary adenoma as judged by the Spearman rank correlation test (P<0.05).
The proliferative activity and abnormal expression of oncogenes DJ-1 and HSP27 may play a significant role in tumorigenesis and progression of pituitary adenoma. There was a significant correlation between the expression of DJ-1 and HSP27 and the invasiveness of pituitary adenoma.
