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冷诱导RNA结合蛋白（CIRP）在垂体腺瘤中的表达及其与肿瘤复发的关系。

Expression of cold-inducible RNA-binding protein (CIRP) in pituitary adenoma and its relationships with tumor recurrence.

作者信息

Wang Mingguang, Zhang Huan, Heng Xueyuan, Pang Qi, Sun Aigang

机构信息

Department of Neurosurgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China (mainland).

Department of Neurosurgery, People's Hospital of Linyi, Linyi, Shandong, China (mainland).

出版信息

Med Sci Monit. 2015 May 2;21:1256-60. doi: 10.12659/MSM.893128.

DOI:10.12659/MSM.893128
PMID:25934796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4428314/
Abstract

BACKGROUND

The aim of this study was to detect the expression of cold-inducible RNA-binding protein in pituitary adenoma and to determine its effects on tumor recurrence.

MATERIAL/METHODS: We collected a total of 60 post-op samples collected from pituitary adenoma patients (including 20 cases of invasive pituitary adenoma, 20 cases of non-invasive adenoma, and 20 cases of non-invasive recurrent adenoma) admitted in our hospital. Both protein and mRNA levels of CIRP in 3 types of pituitary adenoma samples were quantified by Western blotting and real-time PCR, respectively.

RESULTS

Western blotting revealed significantly elevated CIRP expression levels in invasive pituitary adenoma compared to non-invasive tumors, with statistical significance (p<0.05). Recurrent pituitary adenoma expressed significantly higher CIRP levels compared to non-recurrent tumors (p<0.05). Real-time PCR for CIRP mRNA obtained consistent results: transcript levels were significantly higher in invasive pituitary adenoma compared to non-invasive adenoma (p<0.05); recurrent adenoma also had significantly higher CIRP mRNA levels compared to non-recurrent tumors (p<0.05). Among all 3 types of pituitary adenoma, recurrent tumors had the highest levels of CIRP mRNA and protein.

CONCLUSIONS

The expression of CIRP in pituitary adenoma is closely related with tumor proliferation and invasion, and its significantly elevated expression level indicates post-op recurrence.

摘要

背景

本研究旨在检测垂体腺瘤中冷诱导RNA结合蛋白的表达，并确定其对肿瘤复发的影响。

材料/方法：我们收集了我院收治的垂体腺瘤患者术后样本共60份（包括20例侵袭性垂体腺瘤、20例非侵袭性腺瘤和20例非侵袭性复发性腺瘤）。分别通过蛋白质印迹法和实时荧光定量PCR对3种垂体腺瘤样本中CIRP的蛋白质和mRNA水平进行定量分析。

结果

蛋白质印迹法显示，侵袭性垂体腺瘤中CIRP表达水平显著高于非侵袭性肿瘤，差异具有统计学意义（p<0.05）。复发性垂体腺瘤中CIRP水平显著高于非复发性肿瘤（p<0.05）。对CIRP mRNA进行实时荧光定量PCR得到了一致的结果：侵袭性垂体腺瘤中转录水平显著高于非侵袭性腺瘤（p<0.05）；复发性腺瘤中CIRP mRNA水平也显著高于非复发性肿瘤（p<0.05）。在所有3种垂体腺瘤中，复发性肿瘤的CIRP mRNA和蛋白质水平最高。

结论

垂体腺瘤中CIRP的表达与肿瘤增殖和侵袭密切相关，其显著升高的表达水平提示术后复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/bd20dab254cd/medscimonit-21-1256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/ebbdcc9cbe0d/medscimonit-21-1256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/d925e515c638/medscimonit-21-1256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/bd20dab254cd/medscimonit-21-1256-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/ebbdcc9cbe0d/medscimonit-21-1256-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/d925e515c638/medscimonit-21-1256-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ced/4428314/bd20dab254cd/medscimonit-21-1256-g003.jpg

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