Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, PL-01-224 Warsaw, Poland.
Org Biomol Chem. 2012 Jul 21;10(27):5186-8. doi: 10.1039/c2ob25683e. Epub 2012 Jun 1.
The formation of different complexes of folic acid depending on the size of the host cyclodextrin resulting in either an exclusion compound (with the smallest α-cyclodextrin) or 2-rotaxane, where cyclodextrin is threaded over folic acid (with β- and γ-cyclodextrins), is presented. The formation is carried out in water which allows both possible application in pharmaceutical sciences and usage of environmentally friendly "green chemistry". The obtained compounds are thoroughly characterized using one and two dimensional NMR, mass spectrometry, differential scanning calorimetry and thermogravimetric analysis.
本文介绍了叶酸与不同大小的主体环糊精形成不同配合物的情况，根据主体环糊精的不同，形成的配合物要么是包合物（最小的 α-环糊精），要么是 2-轮烷，其中环糊精穿过叶酸（β-和 γ-环糊精）。该反应在水中进行，这既允许它们在药物科学中的两种可能应用，也允许使用环保的“绿色化学”。通过一维和二维 NMR、质谱、差示扫描量热法和热重分析对所得化合物进行了全面表征。
