环糊精轮烷铂配合物及其转化为铂纳米粒子。

Cyclodextrin Rotaxanes of Pt Complexes and Their Conversion to Pt Nanoparticles.

机构信息

Laboratory for Chemistry and Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8503, Japan.

National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.

出版信息

Molecules. 2020 Nov 29;25(23):5617. doi: 10.3390/molecules25235617.

DOI:10.3390/molecules25235617

PMID:33260384

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7729445/

Abstract

The cationic Pt complex (Pt(NCH-CHN-(CH)-O(CH-3,5-(OMe))(MeN-(CHCHNMe))) was prepared by the reaction of alkylbipyridinium ligand with a nitrateplatinum(II) complex. Mixing the complex and α- and β-cyclodextrins in aqueous media produced the corresponding [2]rotaxanes with 1:1 stoichiometry. γ-Cyclodextrin and the Pt complex formed a rotaxane having components in a 1:1 or 2:1 molar ratio. The results of mass and nuclear magnetic resonance (NMR) measurements confirmed the rotaxane structures of the Pt complexes. Transmission electron microscopy (TEM) and atomic force microscope (AFM) analyses revealed the formation of micelles or vesicles. The addition of NaBH to the rotaxanes in aqueous media formed Pt nanoparticles with diameters of 1.3-2.8 nm, as characterized by TEM. The aggregated size of the nanoparticles formed from the rotaxane did not change even at 70 °C, and they showed higher thermal stability than those obtained from the reduction of the cyclodextrin-free Pt complex.

摘要

阳离子 Pt 配合物（Pt(NCH-CHN-(CH)-O(CH-3,5-(OMe))(MeN-(CHCHNMe)))是通过烷基联吡啶配体与硝酸铂（II）配合物反应制备的。在水介质中混合配合物和 α-和 β-环糊精，以 1:1 的化学计量比生成相应的 [2]轮烷。γ-环糊精和 Pt 配合物形成具有 1:1 或 2:1 摩尔比的轮烷。质量和核磁共振（NMR）测量的结果证实了 Pt 配合物的轮烷结构。透射电子显微镜（TEM）和原子力显微镜（AFM）分析表明形成了胶束或囊泡。在水介质中向轮烷中加入 NaBH 形成了直径为 1.3-2.8nm 的 Pt 纳米粒子，这是通过 TEM 表征的。即使在 70°C 下，由轮烷形成的纳米粒子的聚集尺寸也没有变化，并且它们比从无环糊精 Pt 配合物的还原获得的纳米粒子表现出更高的热稳定性。