Departamento de Química Biológica, FCEN, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina.
Cancer Lett. 2012 Dec 1;325(1):11-7. doi: 10.1016/j.canlet.2012.05.031. Epub 2012 Jun 1.
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially, MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MAGE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions.
自 1991 年发现以来，人们对肿瘤特异性黑色素瘤抗原基因（MAGE-I）家族的了解不断增加。最初，MAGE-I 蛋白被认为是免疫治疗的选择性靶标。最近，从 MAGE-I 蛋白控制的不同细胞机制中获得的新数据表明，它们在调节与细胞增殖相关的重要途径方面发挥着关键作用。部分原因是一些 MAGE-I 蛋白能够控制肿瘤抑制因子 p53。在这篇综述中，我们重点讨论了一些解释 MAGE-I 蛋白如何影响 p53 功能的机制。
