Hirose T, Matsumoto I, Aikawa T
J Endocrinol. 1979 Aug;82(2):275-7. doi: 10.1677/joe.0.0820275.
The steroidogenic effect of histamine in isolated adrenocortical cells of the dog was investigated in the presence of prostaglandin E2 (PGE2) and/or dibutyryl cyclic AMP (dbcAMP) in the medium. The effect of histamine, in combination with PGE2 was less than their total individual effects in the production of cortisol, but not ofcorticosterone. With dbcAMP the effect was just equal to them. However, the combination of histamine, PGE2 and dbcAMP showed an increase twice that of their total individual effects in the production of both steroids. These results indicate that, in the dog, histamine, PGE2 and dbcAMP may act synergistically in the adrenocortical cells.
在培养基中存在前列腺素E2（PGE2）和/或二丁酰环磷腺苷（dbcAMP）的情况下，研究了组胺对犬离体肾上腺皮质细胞的类固醇生成作用。组胺与PGE2联合使用时，其在皮质醇生成中的作用小于它们各自单独作用的总和，但在皮质酮生成中并非如此。与dbcAMP联合使用时，其作用与它们单独作用的总和相当。然而，组胺、PGE2和dbcAMP联合使用时，两种类固醇生成的增加量是它们各自单独作用总和的两倍。这些结果表明，在犬中，组胺、PGE2和dbcAMP可能在肾上腺皮质细胞中协同发挥作用。
