Institute for Research in Biomedicine-IRB Barcelona, Barcelona, Spain.
Nat Struct Mol Biol. 2012 Jun 5;19(6):577-85. doi: 10.1038/nsmb.2311.
Beyond the well-known function of poly(A) tail length in mRNA stability, recent years have witnessed an explosion of information about how changes in tail length and the selection of alternative polyadenylation sites contribute to the translational regulation of a large portion of the genome. The mechanisms and factors mediating nuclear and cytoplasmic changes in poly(A) tail length have been studied in great detail, the targets of these mechanisms have been identified--in some cases by genome-wide screenings--and changes in poly(A) tail length are now implicated in a number of physiological and pathological processes. However, in very few cases have all three levels--mechanisms, targets and functions--been studied together.
除了 poly(A) 尾长在 mRNA 稳定性方面的众所周知的功能外，近年来关于尾长变化和选择替代 poly(A) 加尾位点如何有助于基因组大部分区域的翻译调控的信息呈爆炸式增长。介导核和细胞质中 poly(A) 尾长变化的机制和因素已被深入研究，这些机制的靶标已被鉴定——在某些情况下是通过全基因组筛选——poly(A) 尾长的变化现在与许多生理和病理过程有关。然而，在极少数情况下，这三个层面——机制、靶标和功能——都被一起研究过。
