对照组和抑郁症患者血浆总色氨酸的昼夜变化

Diurnal variation in total plasma tryptophan in controls and in depression.

作者信息

Candito M, Souêtre E, Iordache A, Pringuey D, Ardisson J L, Chambon P, Darcourt G

机构信息

Laboratoire de Biochimie, Service du Docteur Chambon, Hôpital Pasteur, Nice, France.

出版信息

J Psychiatr Res. 1990;24(3):227-30. doi: 10.1016/0022-3956(90)90012-f.

DOI:10.1016/0022-3956(90)90012-f

PMID:2266511

Abstract

Circadian rhythms of total tryptophan were investigated by assays of hourly blood samples over 25 h. The study population consisted of four endogenously depressed patients investigated in the absence of any treatment and six healthy controls. The abnormalities detected by statistical analyses in untreated depression consisted mainly of amplitude reduction; the phase positions of the depressed patients were similar to those of the controls.

摘要

通过对25小时内每小时采集的血样进行检测，研究了总色氨酸的昼夜节律。研究对象包括4名未经任何治疗的内源性抑郁症患者和6名健康对照者。未经治疗的抑郁症患者经统计分析检测到的异常主要包括振幅降低；抑郁症患者的相位与对照组相似。