Laufenberg-Feldmann R, Schwab R, Rolke R, Weber M
Klinik für Anästhesiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55131 Mainz, Deutschland.
Anaesthesist. 2012 May;61(5):457-67; quiz 468-9. doi: 10.1007/s00101-012-2022-4.
During the course of cancer progression up to 90% of the patients suffer from pain of nociceptive, neuropathic or mixed nociceptive/neuropathic origin. Psychological, social or existential factors may additionally affect the intensity of pain (concept of "total pain"). The WHO "analgesic ladder" provides a large variety of effective drugs that can be used according to the specific pain type. Parenteral or peridural opioid therapy as well as neurodestructive methods can effectively support the analgesic treatment in selected cases.
在癌症进展过程中，多达90%的患者遭受伤害性、神经性或混合性伤害性/神经性疼痛。心理、社会或生存因素可能会进一步影响疼痛强度（“总疼痛”概念）。世界卫生组织的“镇痛阶梯”提供了多种可根据特定疼痛类型使用的有效药物。在某些特定情况下，胃肠外或硬膜外阿片类药物治疗以及神经毁损方法可有效辅助镇痛治疗。
