Sulila P, Mattsson R
Department of Zoophysiology, University of Uppsala, Sweden.
J Reprod Immunol. 1990 Oct;18(3):259-69. doi: 10.1016/0165-0378(90)90048-b.
Syngeneically mated CBA/Ca mice were used to measure "spontaneous" immunoglobulin (Ig) secretion in the Peyer's patches (PP), spleen and the para-aortic lymph nodes (PALN), employing a protein A plaque assay, during the latter part of pregnancy and in the post-partum period. The lactating and non-lactating females were compared with respect to humoral immune activity (plaque-forming cells) and serum Ig levels (ELISA technique). The pregnancy-induced weight changes in some lymphoid organs and the elevation in the number of plaque-forming cells in spleen (IgG and IgM PFC), PALN (IgG and IgM PFC) and the PP (IgA PFC) lasted longer in the lactating than in the non-lactating mice (owing to hormonal differences). A very strong decrease in serum IgG was observed during pregnancy and after parturition IgG levels remained depressed longer in lactating than in non-lactating mice. Interest has been focused on IgA in the study and this has been discussed as well as the possible reasons for the increased turnover of maternal serum Ig (especially IgG).
在怀孕后期和产后期间，使用同基因交配的CBA/Ca小鼠，采用蛋白A斑试验，来测量派尔集合淋巴结（PP）、脾脏和主动脉旁淋巴结（PALN）中的“自发”免疫球蛋白（Ig）分泌。将哺乳期和非哺乳期雌性小鼠在体液免疫活性（斑形成细胞）和血清Ig水平（ELISA技术）方面进行比较。某些淋巴器官中怀孕引起的体重变化以及脾脏（IgG和IgM PFC）、PALN（IgG和IgM PFC）和PP（IgA PFC）中斑形成细胞数量的增加在哺乳期小鼠中持续的时间比非哺乳期小鼠更长（由于激素差异）。在怀孕期间观察到血清IgG非常显著地下降，并且产后哺乳期小鼠的IgG水平保持较低的时间比非哺乳期小鼠更长。该研究重点关注了IgA，并对其进行了讨论，同时也探讨了母体血清Ig（尤其是IgG）周转增加的可能原因。
