Department of Neurology, Southern General Hospital, Glasgow G51 4TF, UK.
J Neurol Neurosurg Psychiatry. 2012 Jul;83(7):761-2. doi: 10.1136/jnnp-2012-302900.
Some evidence suggests that psychogenic non-epileptic seizures (PNES) are associated with increased mortality. The authors obtained death certificate information in a cohort of 260 patients who presented with PNES between 1999 and 2004. The follow-up period averaged 7.92 years, during which 17 patients died, 12/17 were under the age of 75 years, giving a premature (<75 years) mortality rate of 0.58%, compared with a Scottish mortality rate for the 40-75 years age group of 0.41% per year. The main predictor of death was the patient age at presentation of PNES. There was no correlation with withdrawal of anticonvulsant medication, and death certificate information provided no evidence to suggest that the deaths were related to the seizure disorder. The population had a high mean deprivation rank, providing a possible explanation for a modest increase in premature death rate.
一些证据表明，心因性非癫痫性发作（PNES）与死亡率增加有关。作者在 1999 年至 2004 年间就诊的 260 例 PNES 患者队列中获得了死亡证明信息。随访期平均为 7.92 年，在此期间有 17 名患者死亡，12/17 名患者年龄在 75 岁以下，这意味着过早（<75 岁）死亡率为 0.58%，而苏格兰 40-75 岁年龄组的死亡率为每年 0.41%。死亡的主要预测因素是 PNES 发作时患者的年龄。这与抗惊厥药物的停药无关，死亡证明信息也没有表明死亡与癫痫发作障碍有关。该人群的平均贫困等级较高，这可能是导致过早死亡率略有上升的原因之一。
