Laboratório de Patologia e Biointervenção/CPqGM, Salvador, BA, Brazil.
Am J Trop Med Hyg. 2012 Jun;86(6):966-71. doi: 10.4269/ajtmh.2012.12-0040.
To assess the effect of the rapid removal of potentially infectious dogs on the prevalence and incidence of canine infections, a prospective study was undertaken in an area endemic for Leishmania infantum. We used serological testing based on the rapid DPP rK28 fusion protein chromatographic immunoassay for this dog screening-and-culling intervention trial. The outcome was evaluated by measuring seropositivity and sero-conversion/-reversion rates for canine infection. Our estimates indicated that concomitant detection and elimination of seropositive dogs with active disease may affect the numbers of canine infections and disease burden temporarily, although it is insufficient as a measure to interrupt the zoonotic L. infantum transmission. However, most of the asymptomatic, seropositive dogs continuously exhibit low levels of antibodies and/or reverted, remaining seronegative thereafter. In the process of waiting for an effective vaccine, one option for canine reservoir control may be to identify these possibly genetically resistant animals and promote their expansion in the population.
为了评估快速清除可能具有传染性的犬只对犬类感染的流行率和发病率的影响，在莱什曼原虫流行地区进行了一项前瞻性研究。我们使用基于快速 DPP rK28 融合蛋白层析免疫测定的血清学检测方法进行了这项犬只筛选和扑杀干预试验。通过测量犬类感染的血清阳性率和血清转换/逆转率来评估结果。我们的估计表明，同时检测和消除患有活动性疾病的血清阳性犬只可能会暂时影响犬类感染和疾病负担的数量，尽管作为阻断莱什曼原虫人畜共患传播的措施还不够充分。然而，大多数无症状、血清阳性的犬只持续表现出低水平的抗体和/或逆转，此后保持血清阴性。在等待有效疫苗的过程中，犬类储存控制的一种选择可能是识别这些可能具有遗传抗性的动物，并促进它们在种群中的繁殖。
