Koçer A, Eryılmaz M, Tutkan H, Ercan N, Küçükbayrak Z S
Neurology Department, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
ScientificWorldJournal. 2012;2012:791460. doi: 10.1100/2012/791460. Epub 2012 May 1.
An imbalance of the sympathetic system may explain many of the clinical manifestations of the migraine. We aimed to evaluate P-waves as a reveal of sympathetic system function in migraine patients and healthy controls.
Thirty-five episodic type of migraine patients (complained of migraine during 5 years or more, BMI < 30 kg/m²) and 30 controls were included in our study. We measured P-wave durations (minimum, maximum, and dispersion) from 12-lead ECG recording during pain-free periods. ECGs were transferred to a personal computer via a scanner and then used for magnification of x400 by Adobe Photoshop software.
P-wave durations were found to be similar between migraine patients and controls. Although P WD (P-wave dispersion) was similar, the mean value was higher in migraine subjects. P WD was positively correlated with P max (P < 0.01). Attacks number per month and male gender were the factors related to the P WD (P < 0.01).
Many previous studies suggested that increased sympathetic activity may cause an increase in P WD. We found that P WD of migraine patients was higher than controls, and P WD was related to attacks number per month and male gender. Further studies are needed to explain the chronic effects of migraine.
交感神经系统失衡可能解释偏头痛的许多临床表现。我们旨在评估P波作为偏头痛患者和健康对照者交感神经系统功能的一种揭示指标。
我们的研究纳入了35例发作性偏头痛患者（在5年或更长时间内有偏头痛发作，体重指数<30 kg/m²）和30例对照者。我们在无痛期测量了12导联心电图记录中的P波持续时间（最小值、最大值和离散度）。心电图通过扫描仪传输到个人电脑，然后使用Adobe Photoshop软件放大400倍。
发现偏头痛患者和对照者的P波持续时间相似。尽管P波离散度（PWD）相似，但偏头痛受试者的平均值更高。PWD与P波最大值（Pmax）呈正相关（P<0.01）。每月发作次数和男性性别是与PWD相关的因素（P<0.01）。
许多先前的研究表明，交感神经活动增加可能导致PWD增加。我们发现偏头痛患者的PWD高于对照者，且PWD与每月发作次数和男性性别有关。需要进一步研究来解释偏头痛的慢性影响。
