Colin Pierre, Mordon Serge, Nevoux Pierre, Marqa Mohammed Feras, Ouzzane Adil, Puech Philippe, Bozzini Gregory, Leroux Bertrand, Villers Arnauld, Betrouni Nacim
Inserm U703, Université Lille Nord de France, CHRU Lille, 59037 Lille, France.
Adv Urol. 2012;2012:589160. doi: 10.1155/2012/589160. Epub 2012 May 16.
Current challenges and innovations in prostate cancer management concern the development of focal therapies that allow the treatment of only the cancer areas sparing the rest of the gland to minimize the potential morbidity. Among these techniques, focal laser ablation (FLA) appears as a potential candidate to reach the goal of focusing energy delivery on the identified targets. The aim of this study is to perform an up-to-date review of this new therapeutic modality. Relevant literature was identified using MEDLINE database with no language restrictions (entries: focal therapy, laser interstitial thermotherapy, prostate cancer, FLA) and by cross-referencing from previously identified studies. Precision, real-time monitoring, MRI compatibility, and low cost of integrated system are principal advantages of FLA. Feasibility and safety of this technique have been reported in phase I assays. FLA might eventually prove to be a middle ground between active surveillance and radical treatment. In conclusion, FLA may have found a role in the management of prostate cancer. However, further trials are required to demonstrate the oncologic effectiveness in the long term.
当前前列腺癌治疗中的挑战与创新涉及聚焦疗法的发展，这种疗法能够仅治疗癌灶，而保留腺体的其余部分，以将潜在的发病率降至最低。在这些技术中，聚焦激光消融（FLA）似乎是实现将能量传递聚焦于已识别靶点这一目标的潜在候选方法。本研究的目的是对这种新的治疗方式进行最新综述。使用无语言限制的MEDLINE数据库（条目：聚焦疗法、激光间质热疗、前列腺癌、FLA）并通过对先前已识别研究的交叉引用，确定了相关文献。聚焦激光消融的主要优点包括精确性、实时监测、与MRI兼容以及集成系统成本低。该技术的可行性和安全性已在I期试验中得到报道。聚焦激光消融最终可能会成为主动监测和根治性治疗之间的折衷方案。总之，聚焦激光消融可能已在前列腺癌治疗中发挥作用。然而，需要进一步的试验来证明其长期的肿瘤学有效性。
