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中性内肽酶、内皮素-1和核因子κB在前列腺癌中的表达：根治性前列腺切除术后的相互关系及与前列腺特异性抗原复发的关联

Expression of neutral endopeptidase, endothelin-1, and nuclear factor kappa B in prostate cancer: interrelations and associations with prostate-specific antigen recurrence after radical prostatectomy.

作者信息

Vlachostergios Panagiotis J, Karasavvidou Foteini, Kakkas Grigorios, Moutzouris George, Patrikidou Anna, Voutsadakis Ioannis A, Daliani Danai D, Zintzaras Elias, Melekos Michael D, Papandreou Christos N

机构信息

Department of Medical Oncology, University Hospital of Larissa, University of Thessaly School of Medicine, 41110 Larissa, Greece.

出版信息

Prostate Cancer. 2012;2012:452795. doi: 10.1155/2012/452795. Epub 2012 May 15.

DOI:10.1155/2012/452795
PMID:22666602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3362215/
Abstract

Objective. To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NFκB) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods. 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NFκB (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations. Membranous expression of NEP (P < 0.001), cytoplasmic ET-1 (P = 0.002), and cytoplasmic NFκB (P < 0.001) were correlated with time to PSA relapse. NEP was associated with ET-1 (P < 0.001) and NFκB (P < 0.001). ET-1 was also correlated with NFκB (P < 0.001). NEP expression (P = 0.017), pT stage (P = 0.013), and SMs (P = 0.036) were independent predictors of time to PSA recurrence. Conclusions. There seems to be a clinical model of NEP/NPs and NFκB pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.

摘要

目的。研究中性内肽酶（NEP）/神经肽（NPs）轴和核因子κB（NFκB）作为根治性前列腺切除术（RP）后前列腺特异性抗原（PSA）复发预测指标的影响。患者与方法。70例早期前列腺癌患者接受了RP治疗，并对其肿瘤样本进行NEP、内皮素-1（ET-1）和NFκB（p65）表达评估。PSA复发时间与所检测参数相关，并结合术前PSA水平、Gleason评分、病理TNM（pT）分期和手术切缘（SM）评估。结果与局限性。NEP的膜表达（P < 0.001）、细胞质ET-1（P = 0.002）和细胞质NFκB（P < 0.001）与PSA复发时间相关。NEP与ET-1（P < 0.001）和NFκB（P < 0.001）相关。ET-1也与NFκB相关（P < 0.001）。NEP表达（P = 0.017）、pT分期（P = 0.013）和手术切缘（P = 0.036）是PSA复发时间的独立预测指标。结论。似乎存在一种NEP/NPs和NFκB途径相互连接的临床模型，其组成成分根据其生物学作用和分子相互关系呈现相反的表达模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a227ed33ca87/PC2012-452795.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/05fbf11cef98/PC2012-452795.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/657bb60051db/PC2012-452795.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/b8011f8b2922/PC2012-452795.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a5723585e0e1/PC2012-452795.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a64a0737ee92/PC2012-452795.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a227ed33ca87/PC2012-452795.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/05fbf11cef98/PC2012-452795.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/657bb60051db/PC2012-452795.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/b8011f8b2922/PC2012-452795.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a5723585e0e1/PC2012-452795.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a64a0737ee92/PC2012-452795.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e9b/3362215/a227ed33ca87/PC2012-452795.006.jpg

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