Mannix Rebekah C, Whalen Michael J
Division of Emergency Medicine, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02124, USA.
Int J Alzheimers Dis. 2012;2012:608732. doi: 10.1155/2012/608732. Epub 2012 May 14.
Recently, there has been growing interest in the association between traumatic brain injury (TBI) and Alzheimer's Disease (AD). TBI and AD share many pathologic features including chronic inflammation and the accumulation of beta amyloid (Aβ). Data from both AD and TBI studies suggest that microglia play a central role in Aβ accumulation after TBI. This paper focuses on the current research on the role of microglia response to Aβ after TBI.
最近,创伤性脑损伤(TBI)与阿尔茨海默病(AD)之间的关联越来越受到关注。TBI和AD具有许多病理特征,包括慢性炎症和β淀粉样蛋白(Aβ)的积累。来自AD和TBI研究的数据表明,小胶质细胞在TBI后的Aβ积累中起核心作用。本文重点关注目前关于TBI后小胶质细胞对Aβ反应作用的研究。