Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Mar;113(3):391-8. doi: 10.1016/j.tripleo.2011.08.010.
The objective of this study was to comparatively evaluate the density of lymphatic vessels (LVD) and neoformed microvessels (NMVD) in squamous cell carcinoma of the oral cavity (OCSCC) and lip (LSCC). Association between LVD/NMVD and vascular endothelial growth factor (VEGF)-A/-C was also assessed.
OCSCC and LSCC were compared with regard to immunoexpression of LVD, NMVD, and vascular endothelial growth factor-A (VEGF)-A/-C. Association between VEGF-A/-C with vascularity was also assessed. Statistical analyses were performed using t test, Pearson χ(2), and Mann-Whitney tests. Statistical significance was accepted at P less than .05.
The NMVD and VEGF-C expressions were significantly higher in OCSCC compared with LSCC. NMVD was associated with VEGF-C in OCSCC, but not in LSCC.
Differences in NMVD and VEGF-C were found between OCSCC and LSCC. Positive association between VEGF-C and NMVD was observed in OCSCC, but not in LSCC, which may be one of the contributing factors that account for the distinctive clinical-biological behavior of these lesions.
本研究旨在比较口腔鳞状细胞癌（OCSCC）和唇鳞状细胞癌（LSCC）中淋巴管密度（LVD）和新生微血管密度（NMVD）的密度。还评估了 LVD/NMVD 与血管内皮生长因子（VEGF）-A/-C 之间的相关性。
比较了 OCSCC 和 LSCC 中 LVD、NMVD 和血管内皮生长因子-A（VEGF）-A/-C 的免疫表达。还评估了 VEGF-A/-C 与血管生成之间的相关性。使用 t 检验、Pearson χ(2)和 Mann-Whitney 检验进行统计分析。P 值小于.05 被认为具有统计学意义。
与 LSCC 相比，OCSCC 中的 NMVD 和 VEGF-C 表达显著更高。在 OCSCC 中，NMVD 与 VEGF-C 相关，但在 LSCC 中不相关。
在 OCSCC 和 LSCC 之间发现了 NMVD 和 VEGF-C 的差异。在 OCSCC 中观察到 VEGF-C 和 NMVD 之间的正相关，但在 LSCC 中没有，这可能是这些病变独特的临床生物学行为的一个原因。
