Kanaya N
Department of Biology, Keio University, Yokohama, Japan.
Mutat Res. 1990 Dec;245(4):311-5. doi: 10.1016/0165-7992(90)90162-d.
The induction of sister-chromatid exchanges (SCEs) and chromosome aberrations (CAs) by aniline hydrochloride (AH) and its C-hydroxylated metabolites, o-, m- and p-aminophenol, in the root cells of Vicia faba was examined. AH induced CAs, but not SCEs. All the C-hydroxylated metabolites of aniline induced both SCEs and CAs. However, the treatment of cells with these metabolites at concentrations that did not cause significant increases in CAs resulted in significant increases in SCEs. These results seem to suggest that the substance that induced CAs in root cells treated with AH was not the C-hydroxylated metabolites of aniline.
研究了盐酸苯胺（AH）及其C-羟基化代谢产物邻氨基酚、间氨基酚和对氨基酚对蚕豆根细胞姐妹染色单体交换（SCEs）和染色体畸变（CAs）的诱导作用。AH诱导了CAs，但未诱导SCEs。苯胺的所有C-羟基化代谢产物均诱导了SCEs和CAs。然而，用这些代谢产物处理细胞，在不会导致CAs显著增加的浓度下却导致了SCEs的显著增加。这些结果似乎表明，在用AH处理的根细胞中诱导CAs的物质不是苯胺的C-羟基化代谢产物。
