Kim In-Gun, Kim Dae Yune
Department of Ophthalmology, Maryknoll Hospital, Busan, Korea.
Korean J Ophthalmol. 2012 Jun;26(3):235-8. doi: 10.3341/kjo.2012.26.3.235. Epub 2012 May 22.
We report a case of anterior ischemic optic neuropathy associated with udenafil. A 54-year-old male presented with an acute onset visual field defect of the right eye after udenafil use. Examination revealed a relative afferent pupillary defect and a swollen disc. Automated visual fields revealed an enlarged blind spot and a narrowed visual field. Fluorescein angiography revealed both an inferior choroidal filling delay and an inferior sector filling delay of the optic disc in the arteriovenous phase as well as diffuse leakage of the optic disc in the late phase. Optical coherent tomography revealed increased thickness of the retinal nerve fiber layer, especially in the area of the inferior disc. The patient was counseled to discontinue the use of udenafil and to monitor his blood pressure regularly. The disc swelling was resolved with residual optic atrophy one month after discontinuing the use of udenafil.
我们报告一例与伐地那非相关的前部缺血性视神经病变。一名54岁男性在使用伐地那非后出现右眼急性视野缺损。检查发现相对性传入瞳孔障碍和视盘肿胀。自动视野检查显示盲点扩大和视野变窄。荧光素血管造影显示在动静脉期视盘下方脉络膜充盈延迟和下方扇形充盈延迟，以及晚期视盘弥漫性渗漏。光学相干断层扫描显示视网膜神经纤维层厚度增加，尤其是在视盘下方区域。建议患者停用伐地那非并定期监测血压。停用伐地那非一个月后，视盘肿胀消退，遗留视神经萎缩。
