浅水池，渐逝的记忆——阿尔茨海默病转基因小鼠模型中的空间导航
Wading pools, fading memories-place navigation in transgenic mouse models of Alzheimer's disease.
作者信息
Tanila Heikki
机构信息
A. I. Virtanen Institute, University of Eastern Finland Kuopio, Finland.
出版信息
Front Aging Neurosci. 2012 Jun 1;4:11. doi: 10.3389/fnagi.2012.00011. eCollection 2012.
Abstract
The Morris swim navigation task ("water maze") has been a primary research tool to assess hippocampal-dependent spatial learning and memory in rodents for three decades. Originally developed for rats, its application to mouse studies has been a tedious process, but nowadays there are more studies performed with the Morris swim task in mice than in rats. The task has proved to be particularly useful in demonstrating age-related memory impairment in transgenic mouse models of Alzheimer's disease (AD). This review focuses on task details that are most relevant for its application to mouse studies in general and characteristic patterns of impaired performance in Alzheimer model mice as compared with rodents sustaining hippocampal lesions.
摘要
三十年来，莫里斯水迷宫游泳导航任务一直是评估啮齿动物海马体依赖性空间学习和记忆的主要研究工具。该任务最初是为大鼠开发的，将其应用于小鼠研究是一个繁琐的过程，但如今使用莫里斯游泳任务对小鼠进行的研究比大鼠更多。事实证明，该任务在证明阿尔茨海默病（AD）转基因小鼠模型中与年龄相关的记忆障碍方面特别有用。本综述重点关注与该任务在一般小鼠研究中的应用最相关的任务细节，以及与海马体受损的啮齿动物相比，阿尔茨海默病模型小鼠的受损表现特征模式。
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