菖蒲根茎中的生物活性倍半萜。

Bioactive sesquiterpenoids from the rhizomes of Acorus calamus.

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2012 Jun 22;75(6):1083-9. doi: 10.1021/np300095c. Epub 2012 Jun 6.

DOI:10.1021/np300095c

PMID:22671987

Abstract

Eight new sesquiterpenes (1-8) and one new norsesquiterpene (9) named calamusins A-I were isolated from the ethanol extract of Acorus calamus rhizomes. The absolute configuration of compound 8 was determined by comparing its experimental and calculated ECD spectra. The absolute configurations of the other compounds were determined from their CD spectra. Furthermore, in in vitro assays, compounds 3, 4, 7, and 9 (10 μM) exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage.

摘要

从菖蒲根茎的乙醇提取物中分离得到了 8 个新的倍半萜（1-8）和 1 个新的诺倍半萜（9），命名为菖蒲素 A-I。通过比较化合物 8 的实验和计算 ECD 光谱确定了其绝对构型。其他化合物的绝对构型则根据它们的 CD 光谱确定。此外，在体外实验中，化合物 3、4、7 和 9（10 μM）对 APAP 诱导的 HepG2 细胞损伤表现出较弱的肝保护活性。