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来自土家族民族药（雪通）叶的抗类风湿性关节炎成纤维样滑膜细胞三萜类化合物及保肝木脂素

Anti-RAFLS Triterpenoids and Hepatoprotective Lignans From the Leaves of Tujia Ethnomedicine (Xuetong).

作者信息

Wang Mengyun, Jiang Sai, Hussain Nusrat, Zafar Salman, Xie Qingling, Huang Feibing, Mao Linxi, Li Bin, Jian Yuqing, Wang Wei

机构信息

TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Material Medical Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.

Department of Chemistry, University of Baltistan Skardu, Skardu, Pakistan.

出版信息

Front Chem. 2022 May 10;10:878811. doi: 10.3389/fchem.2022.878811. eCollection 2022.

DOI:10.3389/fchem.2022.878811
PMID:35620653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9127087/
Abstract

A pair of 3,4--cycloartane triterpenoid isomers with a rare peroxy bridge, namely, xuetonins A and B ( and ), four new lignans xuetonlignans A-D (-), a new sesquiterpene xuetonpene (), and a new natural product xuetonin C (), along with 43 known compounds, were obtained from the leaves of Tujia ethnomedicine, . Their structures and configurations were determined with the help of a combination of 1D- and 2D-NMR, HRESIMS spectra, electronic circular dichroism (ECD), and X-ray diffraction data. Compounds , , -, and - showed moderate-to-potent activity against rheumatoid arthritis fibroblast-like synoviocytes (RAFLS) with IC values of 19.81 ± 0.26, 12.73 ± 0.29, 5.70 ± 0.24, 9.25 ± 0.79, 5.66 ± 0.52, 11.91 ± 0.44, 13.22 ± 0.27, and 15.94 ± 0.36 μM, respectively. Furthermore, compounds , , and exhibited significant hepatoprotective effects against -acetyl--aminophenol (APAP)-induced toxicity in HepG2 cells at 10 μM, and the cell viability increased by 12.93, 25.23, and 13.91%, respectively, compared with that in the model group (cf. bicyclol, 12.60%).

摘要

从土家族民族药雪胆（Hemsleya amabilis Diels）的叶子中获得了一对具有罕见过氧桥的3,4-环阿尔廷烷三萜异构体，即雪胆素A和B（1和2）、4个新木脂素雪胆木脂素A-D（3-6）、1个新倍半萜雪胆萜（7）和1个新天然产物雪胆素C（8），以及43个已知化合物。借助一维和二维核磁共振、高分辨电喷雾电离质谱（HRESIMS）、电子圆二色光谱（ECD）和X射线衍射数据确定了它们的结构和构型。化合物1、2、3-6和7对类风湿关节炎成纤维样滑膜细胞（RAFLS）表现出中度至强效活性，IC50值分别为19.81±0.26、12.73±0.29、5.70±0.24、9.25±0.79、5.66±0.52、11.91±0.44、13.22±0.27和15.94±0.36 μM。此外，化合物3、4和7在10 μM时对乙酰氨基酚（APAP）诱导的HepG2细胞毒性表现出显著的保肝作用，与模型组相比，细胞活力分别增加了12.93%、25.23%和13.91%（对比双环醇，为12.60%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/10c21d3b568f/fchem-10-878811-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/debb649fe939/fchem-10-878811-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/439a24d4a9d3/fchem-10-878811-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/6071769b78ab/fchem-10-878811-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/24c914d7d60c/fchem-10-878811-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/391cec9aa1a7/fchem-10-878811-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/af88215da5b4/fchem-10-878811-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/10c21d3b568f/fchem-10-878811-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/debb649fe939/fchem-10-878811-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/439a24d4a9d3/fchem-10-878811-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/6071769b78ab/fchem-10-878811-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/24c914d7d60c/fchem-10-878811-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/391cec9aa1a7/fchem-10-878811-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/af88215da5b4/fchem-10-878811-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dedf/9127087/10c21d3b568f/fchem-10-878811-g007.jpg

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