Demirkol Sait, Kucuk Ugur, Baysan Oben, Balta Sevket, Celik Turgay, Kurt Ibrahim Halil, Kucuk Hilal Olgun, Yuksel Uygar Cagdas, Unlu Murat, Yokusoglu Mehmet
Department of Cardiology, Gulhane Medical Academy, School of Medicine, Ankara, Turkey.
Echocardiography. 2012 Oct;29(9):1064-70. doi: 10.1111/j.1540-8175.2012.01751.x. Epub 2012 Jun 5.
The aim of this study is to investigate the effect of mitral stenosis (MS) on left atrial (LA) function using two-dimensional speckle tracking echocardiography (2DSTE).
The study subjects consisted of 52 patients with asymptomatic MS and 52 control subjects. LA function was assessed using prototype speckle tracking software and manual tracking method. Maximal LA volume (LAVmax) and minimal LA volume (LAVmin) and LA volume before atrial contraction (LAVpre-a) were measured. Using these volumes, LA reservoir, conduit and booster pump fuction parameters were calculated. Indexed LAVmax, LAVmin, and LAVpre-a measurements via speckle tracking were highly correlated with manual tracing methods in both groups. Expansion index (67.8 ± 36.4 vs. 148.3 ± 44.2), diastolic emptying index (37.7 ± 12.9 vs. 58.0 ± 8.5), passive emptying (37.3 ± 14.1 vs. 70.4 ± 10.4) and passive emptying index (13.3 ± 6.3 vs. 41.3 ± 10.6) were decreased significantly in MS patients (P < 0.001). In contrast active emptying index (62.6 ± 4.1 vs. 29.5 ± 10.1) increased in MS group (P < 0.001) while active emptying (28.1 ± 13.0 vs. 28.3 ± 6.9) remained same among both groups.
This is the first study relating LA volumes and function assessed by 2DSTE to MS. 2D speckle tracking analysis of LA volume is relatively easy and provides more detailed information regarding the changes in LA volumes during the cardiac cycle.
本研究旨在使用二维斑点追踪超声心动图（2DSTE）研究二尖瓣狭窄（MS）对左心房（LA）功能的影响。
研究对象包括52例无症状MS患者和52例对照者。使用原型斑点追踪软件和手动追踪方法评估LA功能。测量最大左心房容积（LAVmax）、最小左心房容积（LAVmin）和心房收缩前左心房容积（LAVpre-a）。利用这些容积计算LA储存、管道和助力泵功能参数。两组中通过斑点追踪测得的LAVmax、LAVmin和LAVpre-a的指数测量值与手动追踪方法高度相关。MS患者的扩张指数（67.8±36.4对148.3±44.2）、舒张期排空指数（37.7±12.9对58.0±8.5）、被动排空（37.3±14.1对70.4±10.4）和被动排空指数（13.3±6.3对41.3±10.6）显著降低（P<0.001）。相比之下，MS组的主动排空指数（62.6±4.1对29.5±10.1）升高（P<0.001），而两组间的主动排空（28.1±13.0对28.3±6.9）保持相同。
这是第一项将通过2DSTE评估的LA容积和功能与MS相关联的研究。对LA容积进行二维斑点追踪分析相对容易，并且能提供有关心动周期中LA容积变化的更详细信息。
