• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ABO 血型与人类肠道微生物组成的关联。

Association between the ABO blood group and the human intestinal microbiota composition.

机构信息

The Finnish Red Cross Blood Service, Helsinki, 00310, Finland.

出版信息

BMC Microbiol. 2012 Jun 6;12:94. doi: 10.1186/1471-2180-12-94.

DOI:10.1186/1471-2180-12-94
PMID:22672382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3485159/
Abstract

BACKGROUND

The mucus layer covering the human intestinal epithelium forms a dynamic surface for host-microbial interactions. In addition to the environmental factors affecting the intestinal equilibrium, such as diet, it is well established that the microbiota composition is individually driven, but the host factors determining the composition have remained unresolved.

RESULTS

In this study, we show that ABO blood group is involved in differences in relative proportion and overall profiles of intestinal microbiota. Specifically, the microbiota from the individuals harbouring the B antigen (secretor B and AB) differed from the non-B antigen groups and also showed higher diversity of the Eubacterium rectale-Clostridium coccoides (EREC) and Clostridium leptum (CLEPT) -groups in comparison with other blood groups.

CONCLUSIONS

Our novel finding indicates that the ABO blood group is one of the genetically determined host factors modulating the composition of the human intestinal microbiota, thus enabling new applications in the field of personalized nutrition and medicine.

摘要

背景

覆盖人类肠道上皮的黏液层为宿主-微生物相互作用形成了一个动态表面。除了影响肠道平衡的环境因素（如饮食）外，人们已经充分认识到微生物组的组成是个体驱动的，但决定其组成的宿主因素仍未得到解决。

结果

在这项研究中，我们表明 ABO 血型参与了肠道微生物群相对比例和整体谱的差异。具体来说，携带 B 抗原（分泌型 B 和 AB）的个体的微生物群与非 B 抗原群体不同，与其他血型相比，其真细菌属-梭状芽孢杆菌（Eubacterium rectale-Clostridium coccoides，EREC）和梭状芽胞杆菌属-毛螺菌科（Clostridium leptum，CLEPT）-群的多样性也更高。

结论

我们的新发现表明，ABO 血型是调节人类肠道微生物群组成的遗传决定宿主因素之一，从而为个性化营养和医学领域的新应用提供了可能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/083bfb17e44a/1471-2180-12-94-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/a1288d28be26/1471-2180-12-94-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/3e87415dce56/1471-2180-12-94-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/7f8e14937758/1471-2180-12-94-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/0a14176ab98d/1471-2180-12-94-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/01159acac947/1471-2180-12-94-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/083bfb17e44a/1471-2180-12-94-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/a1288d28be26/1471-2180-12-94-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/3e87415dce56/1471-2180-12-94-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/7f8e14937758/1471-2180-12-94-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/0a14176ab98d/1471-2180-12-94-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/01159acac947/1471-2180-12-94-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3420/3485159/083bfb17e44a/1471-2180-12-94-6.jpg

相似文献

1
Association between the ABO blood group and the human intestinal microbiota composition.ABO 血型与人类肠道微生物组成的关联。
BMC Microbiol. 2012 Jun 6;12:94. doi: 10.1186/1471-2180-12-94.
2
Diets naturally rich in polyphenols and/or long-chain n-3 polyunsaturated fatty acids differently affect microbiota composition in high-cardiometabolic-risk individuals.富含多酚和/或长链 n-3 多不饱和脂肪酸的饮食会对高心血管代谢风险人群的肠道菌群组成产生不同的影响。
Acta Diabetol. 2020 Jul;57(7):853-860. doi: 10.1007/s00592-020-01494-9. Epub 2020 Feb 29.
3
ABO antigen and secretor statuses are not associated with gut microbiota composition in 1,500 twins.在1500对双胞胎中，ABO血型抗原和分泌状态与肠道微生物群组成无关。
BMC Genomics. 2016 Nov 21;17(1):941. doi: 10.1186/s12864-016-3290-1.
4
Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol.健康老年非甾体抗炎药使用者的肠道微生物群会因嗜酸乳杆菌NCFM和乳糖醇的施用而发生选择性改变。
Age (Dordr). 2012 Aug;34(4):987-99. doi: 10.1007/s11357-011-9294-5. Epub 2011 Aug 19.
5
Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment.体外黏液环境动态肠道模型中溃疡性结肠炎患者粪便梭菌/真杆菌属定植减少。
FEMS Microbiol Ecol. 2012 Mar;79(3):685-96. doi: 10.1111/j.1574-6941.2011.01252.x. Epub 2011 Dec 2.
6
PCR DGGE and RT-PCR DGGE show diversity and short-term temporal stability in the Clostridium coccoides-Eubacterium rectale group in the human intestinal microbiota.聚合酶链反应-变性梯度凝胶电泳（PCR-DGGE）和逆转录聚合酶链反应-变性梯度凝胶电泳（RT-PCR-DGGE）显示，人肠道微生物群中球形梭菌-直肠真杆菌组具有多样性和短期时间稳定性。
FEMS Microbiol Ecol. 2006 Dec;58(3):517-28. doi: 10.1111/j.1574-6941.2006.00179.x.
7
Unbalance of intestinal microbiota in atopic children.特应性儿童肠道微生物菌群失衡。
BMC Microbiol. 2012 Jun 6;12:95. doi: 10.1186/1471-2180-12-95.
8
Impact of Selection for Digestive Efficiency on Microbiota Composition in the Chicken.选择消化效率对鸡肠道微生物群组成的影响。
PLoS One. 2015 Aug 12;10(8):e0135488. doi: 10.1371/journal.pone.0135488. eCollection 2015.
9
Evolution of the gut microbiota and the influence of diet.肠道微生物群的演变和饮食的影响。
Benef Microbes. 2013 Mar 1;4(1):31-7. doi: 10.3920/BM2012.0029.
10
Gut microbiota profile in healthy Indonesians.健康印度尼西亚人的肠道微生物群特征。
World J Gastroenterol. 2019 Mar 28;25(12):1478-1491. doi: 10.3748/wjg.v25.i12.1478.

引用本文的文献

1
ABO blood group antigens influence host-microbe interactions and risk of early spontaneous preterm birth.ABO血型抗原影响宿主与微生物的相互作用以及早期自然早产的风险。
NPJ Biofilms Microbiomes. 2025 Sep 10;11(1):170. doi: 10.1038/s41522-025-00783-x.
2
Prevalence and trends of transfusion transmitted infections among blood donors in a tertiary care hospital of Assam.阿萨姆邦一家三级护理医院献血者中输血传播感染的患病率及趋势
Sci Rep. 2025 Aug 16;15(1):30026. doi: 10.1038/s41598-025-97381-w.
3
Blood group O expression in normal tissues and tumors.

本文引用的文献

1
Linking long-term dietary patterns with gut microbial enterotypes.将长期饮食模式与肠道微生物肠型联系起来。
Science. 2011 Oct 7;334(6052):105-8. doi: 10.1126/science.1208344. Epub 2011 Sep 1.
2
Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine.分泌型基因型（FUT2 基因）与人类肠道中双歧杆菌的组成密切相关。
PLoS One. 2011;6(5):e20113. doi: 10.1371/journal.pone.0020113. Epub 2011 May 19.
3
Enterotypes of the human gut microbiome.人类肠道微生物组的肠型。
正常组织和肿瘤中的O血型表达。
FEBS J. 2025 Jun 30. doi: 10.1111/febs.70172.
4
Genomics of host-microbiome interactions in humans.人类宿主-微生物组相互作用的基因组学
Nat Rev Genet. 2025 Jun 4. doi: 10.1038/s41576-025-00849-8.
5
Non-blood type O is associated with an increased likelihood of gestational diabetes development: findings from an updated meta-analysis.非O型血与妊娠期糖尿病发生风险增加相关：一项更新的荟萃分析结果
J Diabetes Metab Disord. 2025 May 30;24(1):133. doi: 10.1007/s40200-025-01653-1. eCollection 2025 Jun.
6
Correlation Of Fut2 And Fut3 Gene Polymorphisms With Inflammatory Bowel Disease In Guangxi Zhuang Population.广西壮族人群中Fut2和Fut3基因多态性与炎症性肠病的相关性
Int J Gen Med. 2025 Mar 1;18:1217-1230. doi: 10.2147/IJGM.S505711. eCollection 2025.
7
eQTL in diseased colon tissue identifies novel target genes associated with IBD.病变结肠组织中的eQTL鉴定出与炎症性肠病相关的新靶基因。
bioRxiv. 2024 Oct 17:2024.10.14.618229. doi: 10.1101/2024.10.14.618229.
8
Glycomics of cervicovaginal fluid from women at risk of preterm birth reveals immuno-regulatory epitopes that are hallmarks of cancer and viral glycosylation.宫颈阴道液糖组学分析揭示了早产风险女性的免疫调节表位，这些表位是癌症和病毒糖基化的特征。
Sci Rep. 2024 Sep 6;14(1):20813. doi: 10.1038/s41598-024-71950-x.
9
Gene Expression Analysis before and after the Pelvic Flexure in the Epithelium of the Equine Hindgut.马后肠上皮中骨盆弯曲前后的基因表达分析
Animals (Basel). 2024 Aug 8;14(16):2303. doi: 10.3390/ani14162303.
10
Non-human peptides revealed in blood reflect the composition of intestinal microbiota.血液中发现的非人类肽反映了肠道微生物群的组成。
BMC Biol. 2024 Aug 26;22(1):178. doi: 10.1186/s12915-024-01975-1.
Nature. 2011 May 12;473(7346):174-80. doi: 10.1038/nature09944. Epub 2011 Apr 20.
4
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.结肠中两层依赖Muc2粘蛋白的黏液层的内层没有细菌。
Gut Microbes. 2010 Jan;1(1):51-54. doi: 10.4161/gmic.1.1.10470.
5
Distribution of in vitro fermentation ability of lacto-N-biose I, a major building block of human milk oligosaccharides, in bifidobacterial strains.人乳寡糖主要结构单元 lacto-N-双糖 I 的体外发酵能力在双歧杆菌菌株中的分布。
Appl Environ Microbiol. 2010 Jan;76(1):54-9. doi: 10.1128/AEM.01683-09. Epub 2009 Oct 23.
6
Sequence analysis of percent G+C fraction libraries of human faecal bacterial DNA reveals a high number of Actinobacteria.对人类粪便细菌DNA的G+C百分比文库进行序列分析，发现大量放线菌。
BMC Microbiol. 2009 Apr 8;9:68. doi: 10.1186/1471-2180-9-68.
7
Microbiomic analysis of the bifidobacterial population in the human distal gut.人体远端肠道中双歧杆菌群体的微生物组学分析。
ISME J. 2009 Jun;3(6):745-51. doi: 10.1038/ismej.2009.19. Epub 2009 Mar 19.
8
A core gut microbiome in obese and lean twins.肥胖与消瘦双胞胎的核心肠道微生物群。
Nature. 2009 Jan 22;457(7228):480-4. doi: 10.1038/nature07540. Epub 2008 Nov 30.
9
Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont.黏膜聚糖觅食增强了一种分解糖类的人体肠道细菌共生体的适应性和传播能力。
Cell Host Microbe. 2008 Nov 13;4(5):447-57. doi: 10.1016/j.chom.2008.09.007.
10
The human microbiome project.人类微生物组计划
Nature. 2007 Oct 18;449(7164):804-10. doi: 10.1038/nature06244.