The Finnish Red Cross Blood Service, Helsinki, 00310, Finland.
BMC Microbiol. 2012 Jun 6;12:94. doi: 10.1186/1471-2180-12-94.
The mucus layer covering the human intestinal epithelium forms a dynamic surface for host-microbial interactions. In addition to the environmental factors affecting the intestinal equilibrium, such as diet, it is well established that the microbiota composition is individually driven, but the host factors determining the composition have remained unresolved.
In this study, we show that ABO blood group is involved in differences in relative proportion and overall profiles of intestinal microbiota. Specifically, the microbiota from the individuals harbouring the B antigen (secretor B and AB) differed from the non-B antigen groups and also showed higher diversity of the Eubacterium rectale-Clostridium coccoides (EREC) and Clostridium leptum (CLEPT) -groups in comparison with other blood groups.
Our novel finding indicates that the ABO blood group is one of the genetically determined host factors modulating the composition of the human intestinal microbiota, thus enabling new applications in the field of personalized nutrition and medicine.
覆盖人类肠道上皮的黏液层为宿主-微生物相互作用形成了一个动态表面。除了影响肠道平衡的环境因素（如饮食）外，人们已经充分认识到微生物组的组成是个体驱动的，但决定其组成的宿主因素仍未得到解决。
在这项研究中，我们表明 ABO 血型参与了肠道微生物群相对比例和整体谱的差异。具体来说，携带 B 抗原（分泌型 B 和 AB）的个体的微生物群与非 B 抗原群体不同，与其他血型相比，其真细菌属-梭状芽孢杆菌（Eubacterium rectale-Clostridium coccoides，EREC）和梭状芽胞杆菌属-毛螺菌科（Clostridium leptum，CLEPT）-群的多样性也更高。
我们的新发现表明，ABO 血型是调节人类肠道微生物群组成的遗传决定宿主因素之一，从而为个性化营养和医学领域的新应用提供了可能。
Zotero 插件
