Kim Jury, Sapp Harold L, Plummer Caryn E, Brooks Dennis E, Kim Daeyoung, Kim Min-Su
College of Veterinary Medicine, Chonbuk National University, 664-14 Duckjin-dong, Duckjin-ku, Jeonju, Korea.
J Vet Med Sci. 2012 Oct;74(10):1359-61. doi: 10.1292/jvms.12-0059. Epub 2012 Jun 1.
The objective of the study was to examine changes of intraocular pressure (IOP) undergoing anesthesia in Rhesus Macaques (Macaca mulatta) with Laser-induced Ocular Hypertension. Twenty male rhesus macaques (hypertensive glaucoma eye in OD; normal eye in OS) between 6 and 20 years of age were used for the study. The monkeys were anesthetized with ketamine hydrochloride (10 mg/kg intramuscularly) and 1% isoflurane, and then IOP in both eyes was measured by a single investigator using a calibrated Tonopen(TM) applanation tonometer (Mentor, Norwell, MA, U.S.A.). The mean IOP with ketamine anesthesia was 36.70 ± 12.04 (right eye: OD) and 15.88 ± 2.84 (left eye: OS). The mean IOP with isoflurane anesthesia was 19.98 ± 6.67 (right eye: OD) and 15.32 ± 2.15 (left eye: OS). Undergoing isoflurane anesthesia, the IOP of OD was significantly decreased. Conclusively, careful examination of IOP is required to prevent unexpected contraindication on glaucoma patient with isoflurane anesthesia.
本研究的目的是检测激光诱导性高眼压的恒河猴（猕猴）在麻醉过程中的眼压变化。选用20只6至20岁的雄性恒河猴（右眼为高血压性青光眼，左眼正常）进行研究。用盐酸氯胺酮（10mg/kg肌肉注射）和1%异氟醚对猴子进行麻醉，然后由一名研究人员使用校准过的托诺笔（Tonopen）压平眼压计（美国马萨诸塞州诺韦尔市的美敦力公司生产）测量双眼眼压。氯胺酮麻醉下的平均眼压，右眼为36.70±12.04，左眼为15.88±2.84。异氟醚麻醉下的平均眼压，右眼为19.98±6.67，左眼为15.32±2.15。在异氟醚麻醉下，右眼眼压显著降低。总之，对于青光眼患者进行异氟醚麻醉时，需要仔细检测眼压，以防止出现意外的禁忌情况。
