纵向研究中早发性精神分裂症的视觉后向掩蔽性能。

Visual backward-masking performance in a longitudinal study of early onset schizophrenia.

机构信息

Vestre Viken Hospital Trust,1309 Rud, Oslo, Norway; Department of Psychology, University of Oslo, Norway.

出版信息

Psychiatry Res. 2012 Dec 30;200(2-3):153-8. doi: 10.1016/j.psychres.2012.05.014. Epub 2012 Jun 4.

DOI:10.1016/j.psychres.2012.05.014

Abstract

The aim of the present study was to examine the effect of visual backward-masking (VBM) in patients with early onset schizophrenia (EOS, n=28) compared to healthy controls (n=80) at baseline and at one- and two-year follow-ups. Seventeen patients and 40 controls performed a VBM task at all three sessions, which included five different interstimuli intervals (ISI) at 16.5, 33.5, 49.5, 116 and 166ms, and an additional no-masking control task. Patients with EOS revealed no impairment of VBM performance at baseline and at the two follow-ups compared to healthy controls at one- and two-year follow-ups. However, the patients demonstrated a deficit of simple early visual processing. Both groups showed effects of development over a period of 24 months for the shortest ISIs.

摘要

本研究旨在考察视觉后向掩蔽（VBM）对早期发病精神分裂症（EOS，n=28）患者的影响，并与健康对照组（n=80）进行比较，观察基线、1 年和 2 年随访时的情况。17 名患者和 40 名对照组在所有三个阶段都进行了 VBM 任务，其中包括 5 个不同的刺激间间隔（ISI），分别为 16.5、33.5、49.5、116 和 166ms，以及一个额外的无掩蔽对照任务。与健康对照组相比，EOS 患者在基线和 1 年和 2 年随访时的 VBM 表现均无损伤。然而，患者表现出简单的早期视觉处理缺陷。两组在 24 个月的时间内都表现出最短 ISI 的发展效应。