Rund Bjørn Rishovd, Egeland Jens, Sundet Kjetil, Asbjørnsen Arve, Hugdahl Kenneth, Landrø Nils Inge, Lund Anders, Roness Atle, Stordal Kirsten I
Institute of Psychology, University of Oslo, P.O. Box 1094, Blindern, N-0317 Oslo, Norway.
Schizophr Res. 2004 Jun 1;68(2-3):111-8. doi: 10.1016/S0920-9964(03)00193-2.
Patients with schizophrenia have repeatedly shown deficits in early visual processing using backward masking (VBM) tasks. Whether this represents a specific dysfunction in schizophrenia is an unsolved question. Patients with recurrent unipolar depression represent an interesting comparison group to examine the question of specificity, but have never previously been assessed on VBM. In addition to comparing VBM performance in patients with schizophrenia and patients with depression, we wanted to examine the relations between VBM and clinical symptoms. Fifty-one patients with schizophrenia were compared to 49 patients with recurrent unipolar depression and 47 healthy controls. All subjects were administered a two-digit identification task in a no-masking and four masking conditions. Patients with schizophrenia performed significantly worse than normal controls on four of the five conditions. No significant difference was found between depression patients and normal controls. The effect of masking stimuli had no differential effects on the three groups. VBM correlated strongly with positive symptoms in the schizophrenia group.
精神分裂症患者在使用逆向掩蔽（VBM）任务进行早期视觉处理时反复表现出缺陷。这是否代表精神分裂症中的一种特定功能障碍仍是一个未解决的问题。复发性单相抑郁症患者是用于检验特异性问题的一个有趣的对照组，但此前从未接受过VBM评估。除了比较精神分裂症患者和抑郁症患者的VBM表现外，我们还想研究VBM与临床症状之间的关系。将51名精神分裂症患者与49名复发性单相抑郁症患者以及47名健康对照进行比较。所有受试者在无掩蔽和四种掩蔽条件下接受两位数识别任务。在五种条件中的四种条件下，精神分裂症患者的表现明显比正常对照组差。抑郁症患者和正常对照组之间未发现显著差异。掩蔽刺激对三组没有差异影响。在精神分裂症组中，VBM与阳性症状密切相关。
