Department of Immunology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Curr Opin Immunol. 2012 Aug;24(4):392-7. doi: 10.1016/j.coi.2012.05.007. Epub 2012 Jun 4.
Foxp3+ CD4+ cells are prominent immune regulatory T (Treg) cells that are most abundant in the intestine. Recent studies have suggested that intestinal Treg cells consist of thymically and extrathymically developed cells that have unique characteristics. A fraction of intestinal Treg cells express T cell receptors that recognize antigens that are derived from the gut microbiota. The presence of the gut microbiota, particularly the Clostridium species, affects the development and function of Treg cells. These intestinal bacteria-induced Treg cells are likely to play a role in the tolerance toward the gut microbiota. These recent advances provide new insight into how T cells are educated in the intestine to maintain homeostasis with the gut microbiota.
Foxp3+ CD4+ 细胞是主要存在于肠道中的突出的免疫调节性 T（Treg）细胞。最近的研究表明，肠道 Treg 细胞由胸腺内和胸腺外发育而来的细胞组成，具有独特的特征。一部分肠道 Treg 细胞表达识别源自肠道微生物群的抗原的 T 细胞受体。肠道微生物群的存在，特别是梭菌属，影响 Treg 细胞的发育和功能。这些由肠道细菌诱导的 Treg 细胞可能在对肠道微生物群的耐受中发挥作用。这些最新进展提供了新的见解，说明 T 细胞如何在肠道中接受教育以与肠道微生物群保持内稳态。
