Etienne-Manneville Sandrine
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 Rue du Dr Roux, 75724, Paris Cedex 15, France,
Subcell Biochem. 2012;60:225-49. doi: 10.1007/978-94-007-4186-7_10.
Migration is a key cellular process, involved during morphogenetic movements as well as in the adult where it participates in immune cell trafficking, wound healing or tumour invasion. As they migrate, cells interact with a microenvironment composed of extracellular matrix and neighbouring cells. Cell-cell adhesions ensure tissue integrity while they allow migration of single or grouped cells within this tissue. Cadherin and nectin-based adherens junctions are key players in intercellular interactions. They are used as adhesive complexes whose mechanical properties improve cell coordination during collective migration and promote cell motility on cadherin substrates. In addition, adherens junctions transduce signals that actively participate in the control of directed cell migration, by providing polarity cues and also participating in contact inhibition of motility.
细胞迁移是一个关键的细胞过程，在形态发生运动期间以及在成体中均有涉及，在成体中它参与免疫细胞运输、伤口愈合或肿瘤侵袭。细胞迁移时，会与由细胞外基质和邻近细胞组成的微环境相互作用。细胞间黏附确保组织完整性，同时允许单个或成组细胞在该组织内迁移。基于钙黏蛋白和NECTIN的黏着连接是细胞间相互作用的关键参与者。它们被用作黏附复合物，其机械特性在集体迁移过程中改善细胞协调性，并促进细胞在钙黏蛋白底物上的运动。此外，黏着连接通过提供极性线索并参与运动接触抑制来转导积极参与定向细胞迁移控制的信号。
