Lechler Terry
Departments of Cell Biology and Dermatology, Duke University Medical Center, 310 Nanaline Duke Bldg, 3709, 27710, Durham, NC, USA,
Subcell Biochem. 2012;60:359-77. doi: 10.1007/978-94-007-4186-7_15.
The specification, maintenance, division and differentiation of stem cells are integral to the development and homeostasis of many tissues. These stem cells often live in specialized anatomical areas, called niches. While niches can be complex, most involve cell-cell interactions that are mediated by adherens junctions. A diverse array of functions have been attributed to adherens junctions in stem cell biology. These include physical anchoring to the niche, control of proliferation and division orientation, regulation of signaling cascades and of differentiation. In this review, a number of model stem cell systems that highlight various functions of adherens junctions are discussed. In addition, a summary of the current understanding of adherens junction function in mammalian tissues and embryonic and induced pluripotent stem cells is provided. This analysis demonstrates that the roles of adherens junctions are surprisingly varied and integrated with both the anatomy and the physiology of the tissue.
干细胞的规格、维持、分裂和分化是许多组织发育和体内平衡所不可或缺的。这些干细胞通常存在于称为龛的特殊解剖区域。虽然龛可能很复杂，但大多数都涉及由黏附连接介导的细胞间相互作用。在干细胞生物学中，黏附连接具有各种各样的功能。这些功能包括与龛的物理锚定、增殖和分裂方向的控制、信号级联反应的调节以及分化的调节。在这篇综述中，讨论了一些突出黏附连接各种功能的模型干细胞系统。此外，还总结了目前对黏附连接在哺乳动物组织、胚胎干细胞和诱导多能干细胞中功能的理解。该分析表明，黏附连接的作用惊人地多样，并与组织的解剖结构和生理学相结合。
